Reactome | Nuclear DUSPs dephosphorylate MAPKs

Nuclear DUSPs dephosphorylate MAPKs

Stable Identifier

R-HSA-5675373

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Class 1 DUSPs, including DUSP 1, 2, 4 and 5 are nuclear and are generally activated by the same extracellular stimuli that promote MAPK signaling, establishing a negative feedback loop. DUSP5 is specific for MAPK3 and 1, while the other class 1 enzymes have broad specificity. Nuclear MAPKs may also be inactivated by nuclear forms of class III DUSPs, including DUSP8, 10 and 16, although the preferred substrate of these enzymes are the p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kondoh and Nishida, 2007).

Literature References

PubMed ID	Title	Journal	Year
17208316	Regulation of MAP kinases by MAP kinase phosphatases Kondoh, K, Nishida, E	Biochim. Biophys. Acta	2007
20463170	The dual-specificity MAP kinase phosphatases: critical roles in development and cancer Bermudez, O, Pagès, G, Gimond, C	Am. J. Physiol., Cell Physiol.	2010
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012