Nuclear DUSPs dephosphorylate MAPKs

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Class 1 DUSPs, including DUSP 1, 2, 4 and 5 are nuclear and are generally activated by the same extracellular stimuli that promote MAPK signaling, establishing a negative feedback loop. DUSP5 is specific for MAPK3 and 1, while the other class 1 enzymes have broad specificity. Nuclear MAPKs may also be inactivated by nuclear forms of class III DUSPs, including DUSP8, 10 and 16, although the preferred substrate of these enzymes are the p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kondoh and Nishida, 2007).

Literature References
PubMed ID Title Journal Year
17208316 Regulation of MAP kinases by MAP kinase phosphatases

Kondoh, K, Nishida, E

Biochim. Biophys. Acta 2007
20463170 The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

Gimond, C, Pag├Ęs, G, Bermudez, O

Am. J. Physiol., Cell Physiol. 2010
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
Catalyst Activity

protein tyrosine/serine/threonine phosphatase activity of nuclear MAPK DUSPs [nucleoplasm]

Orthologous Events
Cite Us!