Reactome | Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

Stable Identifier

R-HSA-997326

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

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The nuclear isoform of T cell protein tyrosine phosphatase (TC-PTP) referred as TC45 (or TC-PTPa) dephosphorylates p-STAT1 dimer in the nucleus. It can also dephosphorylate p-JAK1/3 in IFNG stimulated cells.

Literature References

PubMed ID	Title	Journal	Year
11909529	The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3 Tremblay, ML, Simoncic, PD, Barber, DL, Lee-Loy, A, McGlade, CJ	Curr Biol	2002
12138178	Identification of a nuclear Stat1 protein tyrosine phosphatase Zhu, W, Tremblay, M, de Jesus Ibarra-Sanchez, M, David, M, Fu, Y, Shuai, K, ten Hoeve, J	Mol Cell Biol	2002