Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activation of the cyclin A:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2 (CDK1). This dephosphorylation is achieved by the activity of the CDC25A phosphatase (Timofeev et al. 2009). CDC25A, CDC25B, and CDC25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004).

Literature References
PubMed ID Title Journal Year
19192479 Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases

Timofeev, O, Cizmecioglu, O, Hu, E, Orlik, T, Hoffmann, I

FEBS Lett. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of CDC25A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Created