Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A

Stable Identifier
R-HSA-69199
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
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Cdc25A dephosphorylates Cdk2 and activates cyclin E-Cdk2 and cyclin A-Cdk2 kinases (Blomberg and Hoffmann, 1999).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphoprotein phosphatase activity of CDC25A [nucleoplasm]

Physical Entity
CDC25A [nucleoplasm] (Homo sapiens)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Orthologous Events
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Gallus gallus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Sus scrofa)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Xenopus tropicalis)
Authored
Joshi-Tope, G  (2003-06-12)
Reviewed
Manfredi, JJ  (2018-07-10)
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