PP6-PPP6R3 dephosphorylates TERF2

Stable Identifier
R-HSA-9686524
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The regulatory subunit PPP6R3 of the protein phosphatase complex PP6 facilitates PP6-mediated dephosphorylation of the shelterin subunit TERF2 at serine residue S365. PP6-mediated dephosphorylation of TERF2 occurs at the S phase entry and enables timely loading of RTEL1 to telomere ends (Sarek et al. 2019).
Literature References
PubMed ID Title Journal Year
31723267 CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Snijders, AP, Cesare, AJ, Flynn, HR, Boulton, SJ, Zheng, XF, Margalef, P, Ruis, P, Chowdhury, D, Borel, V, Sarek, G, Van Ly, D, Kotsantis, P

Nature 2019
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PP6-PPP6R3 [nucleoplasm]

Orthologous Events
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