PP6-PPP6R3 dephosphorylates TERF2

Stable Identifier
R-HSA-9686524
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The regulatory subunit PPP6R3 of the protein phosphatase complex PP6 facilitates PP6-mediated dephosphorylation of the shelterin subunit TERF2 at serine residue S365. PP6-mediated dephosphorylation of TERF2 occurs at the S phase entry and enables timely loading of RTEL1 to telomere ends (Sarek et al. 2019).

Literature References
PubMed ID Title Journal Year
31723267 CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Sarek, G, Kotsantis, P, Ruis, P, Van Ly, D, Margalef, P, Borel, V, Zheng, XF, Flynn, HR, Snijders, AP, Chowdhury, D, Cesare, AJ, Boulton, SJ

Nature 2019
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP6-PPP6R3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created
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