The regulatory subunit PPP6R3 of the protein phosphatase complex PP6 facilitates PP6-mediated dephosphorylation of the shelterin subunit TERF2 at serine residue S365. PP6-mediated dephosphorylation of TERF2 occurs at the S phase entry and enables timely loading of RTEL1 to telomere ends (Sarek et al. 2019).
Van Ly, D,
protein serine/threonine phosphatase activity of PP6-PPP6R3 [nucleoplasm]