PPM1A dephosphorylates nuclear SMAD2/3

Stable Identifier
R-HSA-209055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PPM1A dephosphorylates nuclear SMAD2/3
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In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.
Literature References
PubMed ID Title Journal Year
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Lin, X, Duan, X, Liang, YY, Su, Y, Wrighton, KH, Long, J, Hu, M, Davis, CM, Wang, J, Brunicardi, FC, Shi, Y, Chen, YG, Meng, A, Feng, XH

Cell 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm]

Physical Entity
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)
PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)
PPM1A dephosphorylates nuclear SMAD2/3 (Gallus gallus)
PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Sus scrofa)
PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)
Authored
Williams, MG  (2007-03-22)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Williams, MG  (2007-03-27)
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