PP2A dephosphorylates phosphorylated CLK

Stable Identifier
R-DME-432537
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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PP2A dephosphorylates phosphorylated CLK
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The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Clock (CLK) by dephosphorylating it and so prevent it from degradation. CLK levels remain relatively constant because hypophosphorylated CLK is generated by de novo synthesis or by dephosphorylation of existent hyperphosphorylated CLK.
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Catalyst Activity

protein serine/threonine phosphatase activity of PP2A [nucleoplasm]

Physical Entity
PP2A [nucleoplasm] (Drosophila melanogaster)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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