Reactome | RPRD1A [nucleoplasm]

RPRD1A [nucleoplasm]

Stable Identifier

R-HSA-6814899

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Regulation of nuclear pre-mRNA domain-containing protein 1A, RPR1A_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)
      - RPRD1A,B:RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A,B [nucleoplasm] (Homo sapiens)
        
        RPRD1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96P16 RPRD1A

Gene Names

RPRD1A, P15RS

Chain

initiator methionine:, chain:2-312

Reference Genes

COSMIC (genes):RPRD1A RPRD1A

dbSNP Gene:55197 RPRD1A

ENSEMBL:ENSG00000141425 RPRD1A

Participates

as a member of

RPRD1A,B [nucleoplasm] (Homo sapiens)

Inferred To

RTT103 [nucleoplasm] (Saccharomyces cerevisiae)

cids-1 [nucleoplasm] (Caenorhabditis elegans)

rprd1a [nucleoplasm] (Xenopus tropicalis)

Homologues of RPRD1A [nucleoplasm] (Caenorhabditis elegans)

Rprd1a [nucleoplasm] (Mus musculus)

Rprd1a [nucleoplasm] (Rattus norvegicus)

Dmel\CG9018 [nucleoplasm] (Drosophila melanogaster)

RPRD1A [nucleoplasm] (Bos taurus)

RPRD1A [nucleoplasm] (Canis familiaris)

RPRD1A [nucleoplasm] (Gallus gallus)

RPRD1A [nucleoplasm] (Schizosaccharomyces pombe)

RPRD1A [nucleoplasm] (Sus scrofa)

cids-2 [nucleoplasm] (Caenorhabditis elegans)

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53803 POLR2K	2	POLR2K [cytosol] (R-HSA-1964445) POLR2K [nucleoplasm] (R-HSA-63537)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P62875 POLR2L	2	POLR2L [cytosol] (R-HSA-1964467) POLR2L [nucleoplasm] (R-HSA-83715)	0.527	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.502	2