Reactome | p-S40-NFE2L2 [cytosol]

p-S40-NFE2L2 [cytosol]

Stable Identifier

R-HSA-8932290

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:Q16236 NFE2L2

Gene Names

NFE2L2, NRF2

Chain

chain:1-605

Reference Genes

BioGPS Gene:4780 NFE2L2

COSMIC (genes):NFE2L2 NFE2L2

CTD Gene:4780 NFE2L2

dbSNP Gene:4780 NFE2L2

ENSEMBL:ENSG00000116044.17 NFE2L2

HGNC:7782 NFE2L2

KEGG Gene (Homo sapiens):4780 NFE2L2

Monarch:4780 NFE2L2

NCBI Gene:4780 NFE2L2

OMIM:600492 NFE2L2

UCSC:Q16236 NFE2L2

Reference Transcript

Other Identifiers

11739057_a_at

11743380_s_at

1567013_PM_at

1567013_at

16905475

201146_PM_at

201146_at

2588833

2588834

2588835

2588836

2588837

2588838

2588839

2588841

2588843

2588844

2588863

2588864

2588865

2588866

2588867

2588868

2588909

2588910

2588915

2588916

2588924

4780

8056977

853_at

A_23_P5761

A_33_P3225600

GE81603

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006575

GO:0006790

GO:0006954

GO:0007568

GO:0009410

GO:0010033

GO:0010226

GO:0010499

GO:0010628

GO:0010667

GO:0010976

GO:0012501

GO:0016567

GO:0019904

GO:0023052

GO:0030154

GO:0030163

GO:0030194

GO:0030968

GO:0032993

GO:0034599

GO:0034976

GO:0036003

GO:0036211

GO:0036499

GO:0042060

GO:0042149

GO:0043161

GO:0043226

GO:0043536

GO:0043565

GO:0045088

GO:0045454

GO:0045766

GO:0045893

GO:0045944

GO:0045995

GO:0046223

GO:0046326

GO:0048856

GO:0048870

GO:0055085

GO:0060548

GO:0061419

GO:0061629

GO:0070301

GO:0071280

GO:0071356

GO:0071456

GO:0071466

GO:0071498

GO:0071499

GO:0090575

GO:0098542

GO:0098754

GO:0140110

GO:0140467

GO:1900407

GO:1902037

GO:1902176

GO:1903071

GO:1903206

GO:1903788

GO:1904385

GO:1904753

GO:2000121

GO:2000352

GO:2000379

HMNXSV003047979

ILMN_1790909

PH_hs_0009358

S74017_at

TC02005045.hg

g5453775_3p_at

Participates

as an output of

PKC phosphorylates NFE2L2 (Homo sapiens)

as a candidate of

p-NFE2L2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S40, S344, S347- NFE2L2 [nucleoplasm]

p-S344, S347,T-NFE2L2 [nucleoplasm]

ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]

ub-p-S335, S338,T-NFE2L2 [nucleoplasm]

p-S40-18 AcK-NFE2L2 [nucleoplasm]

p-S,T-18 AcK-NFE2L2 [nucleoplasm]

ub-NFE2L2 [cytosol]

NFE2L2 [cytosol]

p-S,T-NFE2L2 [cytosol]

p-S,T-NFE2L2 [nucleoplasm]

p-S40-NFE2L2 [nucleoplasm]

Inferred To

phospho-skn-1 [cytosol] (Caenorhabditis elegans)

phospho-nfe2l2 [cytosol] (Xenopus tropicalis)

phospho-p-S40-NFE2L2 [cytosol] (Canis familiaris)

phospho-p-S40-NFE2L2 [cytosol] (Danio rerio)

phospho-p-S40-NFE2L2 [cytosol] (Gallus gallus)

phospho-NFE2L2 [cytosol] (Bos taurus)

phospho-NFE2L2 [cytosol] (Sus scrofa)

phospho-cnc [cytosol] (Drosophila melanogaster)

phospho-Nfe2l2 [cytosol] (Mus musculus)

phospho-Nfe2l2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 40

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001138885.1, NP_001300830.1, NP_006155.2, NP_001138884.1, NP_001300829.1

Guide to Pharmacology - Targets

3057

OpenTargets

ENSG00000116044

ZINC - Substances

NF2L2_HUMAN

ZINC target

Q16236

ZINC - Biogenic

NF2L2_HUMAN

PRO

Q16236

PDB

7X5G, 7K28, 2LZ1, 7K2D, 6T7V, 7X5F, 7K2K, 7K2A, 4IFL, 3ZGC, 7O7B, 7K2C, 5WFV, 7K2E, 7K2B, 2FLU, 7X5E, 7K29

HPA

ENSG00000116044-NFE2L2

GeneCards

Q16236

Ensembl

ENST00000397062, ENST00000397063, ENST00000464747, ENSP00000467401, ENSP00000411575, ENSG00000116044, ENST00000446151, ENSP00000380253, ENSP00000380252

Pharos - Targets

Q16236

ZINC - Predictions - Purchasable

NF2L2_HUMAN

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.972	34
UniProt:O15525 MAFG	1	MAFG [nucleoplasm] (R-HSA-1008212)	0.911	12
UniProt:O60675 MAFK	1	MAFK [nucleoplasm] (R-HSA-1008242)	0.749	6
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.727	8
IntAct:EBI-4399559 UBIQ			0.667	3
UniProt:P13805 TNNT1	1	TNNT1 [cytosol] (R-HSA-390544)	0.666	4
UniProt:O60519 CRBL2			0.625	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.625	5
UniProt:O15144 ARPC2	1	ARPC2 [cytosol] (R-HSA-200809)	0.625	5
UniProt:P43268 ETV4	1	ETV4 [nucleoplasm] (R-HSA-5687030)	0.625	6
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.625	5
UniProt:Q10587 TEF			0.625	5
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.625	5
UniProt:P41212 ETV6	14	p-12Y ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912) p-11Y ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-338insGCS)-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-154insGSFILG)-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-384)-p-3Y FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-384)-p-6Y FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154insGSFILG)-p-6Y FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-338insGCS)-p-6Y FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y FLT3(574-993) fusion [cytosol] (R-HSA-9703318)	0.625	5
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.625	5
UniProt:Q9NS37 ZHANG			0.625	5
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.625	5
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.625	5
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.625	5
UniProt:P15408 FOSL2			0.625	6
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.625	6
UniProt:P52564 MAP2K6	3	p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) MAP2K6 [cytosol] (R-HSA-167998)	0.625	5
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.625	5
UniProt:Q9ULX9 MAFF	1	MAFF [nucleoplasm] (R-HSA-1008261)	0.609	3
UniProt:Q13342 SP140			0.581	4
UniProt:O94916 NFAT5			0.581	4
UniProt:P50549 ETV1			0.581	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.581	4
UniProt:P78545 ELF3	2	ELF3 [nucleoplasm] (R-HSA-9021353) p-S68-ELF3 [nucleoplasm] (R-HSA-9021349)	0.581	5
UniProt:Q9BTA9 WAC	1	WAC [nucleoplasm] (R-HSA-8942150)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	5
UniProt:P13805-3 TNNT1			0.556	3
UniProt:Q60953	4	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-MMU-3000440) PML [nucleoplasm] (R-MMU-1031706)	0.544	2
UniProt:P11416 Rara	3	phospho-Rara [nucleoplasm] (R-MMU-5334830) Rara [nucleoplasm] (R-MMU-5618000) Rara [nucleoplasm] (R-MMU-4341042)	0.544	2
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.524	2
UniProt:Q9UJU2 LEF1	2	pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389) LEF1 [nucleoplasm] (R-HSA-3214972)	0.508	3
UniProt:Q9ULD4 BRPF3	3	BRPF3 [extracellular region] (R-HSA-350700) BRPF3 [cytosol] (R-HSA-350716) BRPF3 [nucleoplasm] (R-HSA-3318471)	0.508	3
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.508	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.508	4
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642) CASP7(2-303) [cytosol] (R-HSA-57029)	0.508	2
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.508	2
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.508	2
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.508	2
UniProt:Q6V702 CF299			0.508	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.508	2
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.508	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.508	2
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.508	3
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.508	5
UniProt:Q77UU1 Q77UU1			0.488	2
UniProt:O95718-3 ESRRB			0.463	2

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