KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

Stable Identifier
R-HSA-9011985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
KDM1A removes the H3K9me2 repressive epigenetic mark at estrogen-responsive enhancers, allowing transcriptional activation (Wang et al, 2009; Su et al, 2014).
Literature References
PubMed ID Title Journal Year
19098913 The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Sun, W, Kurash, JK, Gaudet, F, Xu, G, Gay, F, Chang, H, Li, E, Wang, J, Chen, T, Bajko, J, Su, H, Lei, H, Hevi, S

Nat. Genet. 2009
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Hsu, MT, Tzeng, TY, Cheng, C, Su, CH

Nucleic Acids Res. 2014
Participants
Participates
Catalyst Activity

histone H3-methyl-lysine-9 demethylase activity of MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!