KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

Stable Identifier
R-HSA-9011985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
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KDM1A removes the H3K9me2 repressive epigenetic mark at estrogen-responsive enhancers, allowing transcriptional activation (Wang et al, 2009; Su et al, 2014).
Literature References
PubMed ID Title Journal Year
19098913 The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Sun, W, Kurash, JK, Gaudet, F, Xu, G, Gay, F, Chang, H, Li, E, Wang, J, Chen, T, Bajko, J, Su, H, Lei, H, Hevi, S

Nat. Genet. 2009
24371278 An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells

Hsu, MT, Tzeng, TY, Cheng, C, Su, CH

Nucleic Acids Res. 2014
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Output
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as an event of
Catalyst Activity

histone H3K9 demethylase activity of MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm]

Physical Entity
MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Homo sapiens)
Activity
histone H3K9 demethylase activity (GO:0032454)
Orthologous Events
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Bos taurus)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Drosophila melanogaster)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Rattus norvegicus)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Saccharomyces cerevisiae)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Schizosaccharomyces pombe)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Sus scrofa)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Xenopus tropicalis)
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-07)
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