Reactome | KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

Stable Identifier

R-HSA-9011985

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KDM1A demethylates H3 on MYC and BCL genes in response to estrogen

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KDM1A removes the H3K9me2 repressive epigenetic mark at estrogen-responsive enhancers, allowing transcriptional activation (Wang et al, 2009; Su et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
19098913	The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation Wang, J, Hevi, S, Kurash, JK, Lei, H, Gay, F, Bajko, J, Su, H, Sun, W, Chang, H, Xu, G, Gaudet, F, Li, E, Chen, T	Nat. Genet.	2009
24371278	An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells Su, CH, Tzeng, TY, Cheng, C, Hsu, MT	Nucleic Acids Res.	2014