ZNF217 binds CDH1 gene promoter

Stable Identifier
R-HSA-9768067
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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ZNF217 binds CDH1 gene promoter
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By chromatin immunoprecipitation (ChIP) (Cowger et al. 2007, Si et al. 2019) and electromobility shift assay (EMSA) (Nunez et al. 2012), ZNF217 binds to the promoter of the CDH1 gene, recruiting histone demethylase KDM1A (LSD1) (Cowger et la. 2007, Si et al. 2019) and possibly also CTBP1 and RCOR1 (CoREST) (Cowger et al. 2007).
Literature References
PubMed ID Title Journal Year
30898548 The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101

Si, W, Zhao, Y, Zhou, J, Zhang, Q, Zhang, Y

Exp Cell Res 2019
17130829 Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence

Cowger, JJ, Zhao, Q, Isovic, M, Torchia, J

Oncogene 2007
21908891 The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain

Nunez, N, Clifton, MMK, Funnell, APW, Artuz, C, Hallal, S, Quinlan, KGR, Font, J, Vandevenne, M, Setiyaputra, S, Pearson, RCM, Mackay, JP, Crossley, M

J Biol Chem 2011
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Authored
Orlic-Milacic, M  (2022-03-03)
Created
Orlic-Milacic, M  (2022-03-03)
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