Reactome | HAUS6 [cytosol]

HAUS6 [cytosol]

Stable Identifier

R-HSA-8855196

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HAUS augmin-like complex subunit 6, DGT6, FAM29A, KIAA1574, HAUS6_HUMAN

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z4H7 HAUS6

Gene Names

HAUS6, DGT6, FAM29A, KIAA1574

Chain

chain:1-955

Reference Genes

BioGPS Gene:54801 HAUS6

COSMIC (genes):HAUS6 HAUS6

CTD Gene:54801 HAUS6

dbSNP Gene:54801 HAUS6

ENSEMBL:ENSG00000147874 HAUS6

HGNC:25948 HAUS6

KEGG Gene (Homo sapiens):54801 HAUS6

Monarch:54801 HAUS6

NCBI Gene:54801 HAUS6

OMIM:613433 HAUS6

UCSC:Q7Z4H7 HAUS6

Reference Transcript

Other Identifiers

0006420044

11727486_at

11727487_at

11727488_s_at

11750151_a_at

17092688

218602_s_at

222685_at

233655_s_at

3002216

3002219

3002220

3002221

3002222

3002266

3002267

3002321

3002326

3002328

3200610

3200612

3200613

3200614

3200615

3200616

3200617

3200620

3200621

3200622

3200624

3200625

3200626

3200631

3200632

3200633

3200635

3200636

3200637

3200638

3200639

3200640

3200641

3200642

3200645

3200646

3200647

51824_at

54801

63946_r_at

65066_at

8132843

8160284

A_23_P146347

A_24_P226949

A_24_P941148

A_32_P3290

GE55352

GO:0000086

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0007010

GO:0007049

GO:0007098

GO:0008150

GO:0010389

GO:0016607

GO:0022607

GO:0032991

GO:0034451

GO:0043226

GO:0051225

GO:0051301

GO:0070652

GO:0097711

Hs.54617.0.S2_3p_at

Hs.54617.1.S1_3p_a_at

ILMN_1653332

ILMN_1664139

PH_hs_0027655

TC09000933.hg

g8923062_3p_a_at

Participant Of

hasComponent

HAUS complex [cytosol]

Inferred To

Haus6 [cytosol] (Mus musculus)

HAUS6 [cytosol] (Bos taurus)

HAUS6 [cytosol] (Canis familiaris)

HAUS6 [cytosol] (Gallus gallus)

HAUS6 [cytosol] (Sus scrofa)

Fam29a [cytosol] (Rattus norvegicus)

haus6 [cytosol] (Danio rerio)

haus6 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_060115.3, NP_001257819.1

OpenTargets

ENSG00000147874

GeneCards

Q7Z4H7

HPA

ENSG00000147874-HAUS6

Ensembl

ENST00000380502, ENSP00000369871, ENSG00000147874

PRO

Q7Z4H7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.502	2

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