Reactome | FGG [platelet alpha granule lumen]

FGG [platelet alpha granule lumen]

Stable Identifier

R-HSA-140922

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

fibrinogen gamma chain

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
        
        fibrinogen [platelet alpha granule lumen] (Homo sapiens)
        
        FGG [platelet alpha granule lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02679 FGG

Gene Names

FGG, PRO2061

Chain

signal peptide:1-26, chain:27-453

Reference Genes

BioGPS Gene:2266 FGG

COSMIC (genes):FGG FGG

CTD Gene:2266 FGG

dbSNP Gene:2266 FGG

ENSEMBL:ENSG00000171557 FGG

HGNC:3694 FGG

KEGG:hsa:2266 FGG

Monarch:2266 FGG

NCBI Gene:2266 FGG

OMIM:134850 FGG

UCSC:P02679 FGG

Reference Transcript

Other Identifiers

11724508_s_at

11743159_x_at

16980849

219612_PM_s_at

219612_s_at

2266

2790653

2790654

2790655

2790656

2790657

2790658

2790659

2790662

2790663

2790664

2790666

2790667

2790668

2790669

2790670

2790671

2790672

2790673

2790674

2790675

2790676

2790677

2790678

2790679

2790680

2790681

2790683

2790684

2790685

2790686

2790687

36622_at

64306_at

74775_s_at

8103326

A_23_P148088

GE58226

GE63243

GO:0003013

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005577

GO:0005615

GO:0005788

GO:0005886

GO:0007155

GO:0007160

GO:0007596

GO:0009306

GO:0009897

GO:0009986

GO:0030168

GO:0030312

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0034116

GO:0036345

GO:0042730

GO:0042802

GO:0043226

GO:0045907

GO:0045921

GO:0046872

GO:0050714

GO:0050839

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0071347

GO:0071354

GO:0072378

GO:0072562

GO:0090277

GO:1900026

GO:1902042

GO:2000352

HMNXSV003023104

ILMN_1703188

ILMN_1737683

ILMN_2315044

M10014_cds1_at

PH_hs_0004325

PH_hs_0031320

TC04001663.hg

TC04002794.hg

g11761634_3p_at

g11761634_3p_x_at

Participates

as a component of

fibrinogen [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

FGG [extracellular region]

FGG [plasma membrane]

FGG [endoplasmic reticulum lumen]

p-FGG [endoplasmic reticulum lumen]

Inferred To

FGG [platelet alpha granule lumen] (Gallus gallus)

FGG [platelet alpha granule lumen] (Mus musculus)

FGG [platelet alpha granule lumen] (Rattus norvegicus)

FGG [platelet alpha granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_000500.2, NP_068656.2

OpenTargets

ENSG00000171557

ENSEMBL

ENST00000336098, ENSG00000171557, ENSP00000336829, ENST00000404648, ENSP00000384860

HPA

ENSG00000171557-FGG

GeneCards

FGG

PRO

P02679

Pharos - Targets

P02679

Orphanet

FGG

GlyGen

P02679

HMDB Protein

HMDBP01954

PDB

2VDR, 3GHG, 2Z4E, 3E1I, 2XNX, 2XNY, 2VDQ, 2HOD, 2H43, 1RE4, 2A45, 2OYH, 1RF0, 2FFD, 2HWL, 1DUG, 1RF1, 2OYI, 2VDO, 2FIB, 1FID, 2HPC, 1N8E, 2Y7L, 1FIC, 3HUS, 2Q9I, 1FIB, 3H32, 1RE3, 3FIB, 1N86, 2VR3, 1FZC, 1FZA, 1FZB, 2HLO, 3BVH, 4B60, 2VDP, 1LTJ, 1FZG, 1FZF, 1FZE, 1LT9

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02671 FGA	8	FGA [extracellular region] (R-HSA-140583) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [plasma membrane] (R-HSA-140916) FGA(20-866) [extracellular region] (R-HSA-140841) FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905)	0.852	11
UniProt:P78423 CX3CL1	1	CX3CL1 [extracellular region] (R-HSA-373368)	0.524	3