Reactome | RCOR1 [nucleoplasm]

RCOR1 [nucleoplasm]

Stable Identifier

R-HSA-996766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

REST corepressor 1, RCOR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
        
        CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
        
        CoREST complex [nucleoplasm] (Homo sapiens)
        
        RCOR1 [nucleoplasm] (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
        
        CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
        
        CoREST complex [nucleoplasm] (Homo sapiens)
        
        RCOR1 [nucleoplasm] (Homo sapiens)
        
        PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
        
        CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
        
        CoREST complex [nucleoplasm] (Homo sapiens)
        
        RCOR1 [nucleoplasm] (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
        
        NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
        
        CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
        
        CoREST complex [nucleoplasm] (Homo sapiens)
        
        RCOR1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UKL0 RCOR1

Gene Names

RCOR1, KIAA0071, RCOR

Chain

chain:1-485

Reference Genes

BioGPS Gene:23186 RCOR1

COSMIC (genes):RCOR1 RCOR1

CTD Gene:23186 RCOR1

dbSNP Gene:23186 RCOR1

ENSEMBL:ENSG00000089902 RCOR1

HGNC:17441 RCOR1

KEGG:hsa:23186 RCOR1

Monarch:23186 RCOR1

NCBI Gene:23186 RCOR1

OMIM:607675 RCOR1

UCSC:Q9UKL0 RCOR1

Reference Transcript

RefSeq:NM_015156.3 RCOR1

Other Identifiers

11718560_at

11718561_at

16789059

212612_PM_at

212612_at

23186

237041_3p_x_at

237041_PM_x_at

237041_x_at

3553238

3553239

3553240

3553241

3553242

3553266

3553274

3553277

3553278

3553279

3553280

3553281

3553283

3553284

3553286

3553287

3553288

3553289

3553294

3553295

3553296

3553297

3553298

3553299

37651_at

7977003

82596_r_at

A_14_P104582

A_23_P205247

A_24_P330366

A_24_P87257

A_33_P3211924

D31888_at

GE57171

GE81991

GO:0000118

GO:0003682

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006325

GO:0006355

GO:0006357

GO:0010629

GO:0017053

GO:0019899

GO:0030154

GO:0030218

GO:0043226

GO:0045654

GO:0045892

GO:0060090

GO:0140110

GO:1990391

HMNXSV003029710

Hs.167048.0.A1_3p_at

Hs.167048.0.A1_3p_x_at

Hs.78398.0.S2_3p_at

ILMN_1743421

PH_hs_0035904

TC14000784.hg

Participates

as a component of

Inferred To

CoRest [nucleoplasm] (Drosophila melanogaster)

spr-1 [nucleoplasm] (Caenorhabditis elegans)

RCOR1 [nucleoplasm] (Bos taurus)

RCOR1 [nucleoplasm] (Caenorhabditis elegans)

RCOR1 [nucleoplasm] (Canis familiaris)

RCOR1 [nucleoplasm] (Gallus gallus)

RCOR1 [nucleoplasm] (Sus scrofa)

rcor1 [nucleoplasm] (Danio rerio)

rcor1 [nucleoplasm] (Xenopus tropicalis)

Homologues of RCOR1 [nucleoplasm] (Caenorhabditis elegans)

Rcor1 [nucleoplasm] (Mus musculus)

Rcor1 [nucleoplasm] (Rattus norvegicus)

rcor-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_055971.2

OpenTargets

ENSG00000089902

ENSEMBL

ENSP00000262241, ENST00000262241

HPA

ENSG00000089902-RCOR1

PRO

Q9UKL0

Pharos - Targets

Q9UKL0

GlyGen

Q9UKL0

PDB

2XAS, 8Q1G, 4UV9, 2XAH, 5L3D, 2XAQ, 5L3E, 6KGK, 7ZRY, 8Q1J, 4UV8, 2XAG, 5X60, 2Y48, 5LGN, 8FDV, 5L3C, 4KUM, 7CDD, 7CDG, 5LBQ, 6S35, 5LHG, 5L3F, 5LHH, 7CDF, 5LGU, 5H6R, 8BOP, 6KGM, 2XAJ, 8F2Z, 8F6S, 8BOX, 3ZN1, 5YJB, 8JF5, 4UVB, 4UVA, 4UVC, 2UXN, 5LHI, 3ZN0, 6K3E, 2V1D, 4XBF, 3ZMV, 2XAF, 8Q1H, 2X0L, 6TUY, 6W4K, 8F59, 2UXX, 3ZMT, 5L3B, 7CDE, 2IW5, 4UXN, 3ZMU, 6TE1, 6VYP, 5L3G, 4BAY, 5LGT, 3ZMS, 5H6Q, 3ZMZ, 8F30, 6KGL, 8YM7, 6KGN, 6WC6, 7CDC

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.945	15
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.897	9
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.837	6
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.788	11
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.643	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	2
UniProt:P0DPD6 ECE2	1	ECE2 [transport vesicle membrane] (R-HSA-9608272)	0.527	3
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.462	3