Reactome | MTA3 [nucleoplasm]

MTA3 [nucleoplasm]

Stable Identifier

R-HSA-4657013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Metastasis-associated protein MTA3, MTA3_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
        
        MTA3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BTC8 MTA3

Gene Names

MTA3, KIAA1266

Chain

chain:1-594

Reference Genes

BioGPS Gene:57504 MTA3

COSMIC (genes):MTA3 MTA3

CTD Gene:57504 MTA3

dbSNP Gene:57504 MTA3

ENSEMBL:ENSG00000057935 MTA3

ENSEMBL_homo_sapiens_GENE:ENSG00000057935.14 MTA3

HGNC:23784 MTA3

KEGG Gene (Homo sapiens):57504 MTA3

Monarch:57504 MTA3

NCBI Gene:57504 MTA3

OMIM:609050 MTA3

UCSC:Q9BTC8 MTA3

Reference Transcript

Other Identifiers

11754731_a_at

223311_PM_s_at

223311_s_at

226852_PM_at

226852_at

2478942

2478943

2478948

2478950

2478952

2478955

2478957

2478961

2478964

2478965

2478974

2478978

2478981

2478984

2478985

2478986

2478987

2478989

2478990

2478991

2478992

2478993

2478997

2478998

2479005

2479006

2479007

2479008

2479009

2479010

2479011

2479012

2479013

2479014

2479015

2479016

47932_at

53186_s_at

53187_at

57504

59743_at

79737_at

8041617

A_23_P154522

A_23_P411431

GE53858

GE88574

GO:0000086

GO:0000122

GO:0000278

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008283

GO:0010971

GO:0016581

GO:0030154

GO:0042659

GO:0042826

GO:0043226

GO:0043231

GO:0043565

GO:0044877

GO:0045892

GO:0045893

GO:0046872

GO:0120325

GO:0140110

GO:1904197

GO:1990739

GO:2000736

HMNXSV003055806

Hs.58598.1.S1_3p_at

ILMN_1768751

PH_hs_0020413

PH_hs_0036736

g13278950_3p_a_at

g13278950_3p_x_at

Participates

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)

Inferred To

MTA1-like [nucleoplasm] (Drosophila melanogaster)

lin-40 [nucleoplasm] (Caenorhabditis elegans)

Mta3 [nucleoplasm] (Mus musculus)

Mta3 [nucleoplasm] (Rattus norvegicus)

MTA3 [nucleoplasm] (Bos taurus)

MTA3 [nucleoplasm] (Canis familiaris)

MTA3 [nucleoplasm] (Gallus gallus)

MTA3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001317371.1, NP_065795.1, NP_001269685.1, NP_001269684.1

OpenTargets

ENSG00000057935

GeneCards

Q9BTC8

HPA

ENSG00000057935-MTA3

Ensembl

ENSP00000385823, ENSG00000057935, ENSP00000385045, ENST00000407270, ENST00000405094

PRO

Q9BTC8

Pharos - Targets

Q9BTC8

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.788	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	5
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.643	4
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.612	18
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.612	18
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	4

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