Reactome | NR1H3 [nucleoplasm]

NR1H3 [nucleoplasm]

Stable Identifier

R-HSA-8854957

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Oxysterols receptor LXR-alpha, NR1H3_HUMAN

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Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ABCA1 (Homo sapiens)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
        
        NR1H2,3:RXR [nucleoplasm] (Homo sapiens)
        
        NR1H3:RXRA [nucleoplasm] (Homo sapiens)
        
        NR1H3 [nucleoplasm] (Homo sapiens)
        
        NR1H3:RXRB [nucleoplasm] (Homo sapiens)
        
        NR1H3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13133 NR1H3

Gene Names

NR1H3, LXRA

Chain

chain:1-447

Reference Genes

BioGPS Gene:10062 NR1H3

COSMIC (genes):NR1H3 NR1H3

CTD Gene:10062 NR1H3

dbSNP Gene:10062 NR1H3

ENSEMBL:ENSG00000025434 NR1H3

HGNC:7966 NR1H3

KEGG:hsa:10062 NR1H3

Monarch:10062 NR1H3

NCBI Gene:10062 NR1H3

OMIM:602423 NR1H3

UCSC:Q13133 NR1H3

Reference Transcript

Participates

as an output of

NR1H3 mRNA is translated (Homo sapiens)

as a component of

as a member of

NR1H2,NR1H3 [nucleoplasm] (Homo sapiens)

Inferred To

NR1H3 [nucleoplasm] (Bos taurus)

NR1H3 [nucleoplasm] (Canis familiaris)

NR1H3 [nucleoplasm] (Gallus gallus)

NR1H3 [nucleoplasm] (Sus scrofa)

nr1h3 [nucleoplasm] (Danio rerio)

EcR [nucleoplasm] (Drosophila melanogaster)

Nr1h3 [nucleoplasm] (Mus musculus)

Nr1h3 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005252766.1, XP_047282150.1, XP_005252770.1, XP_005252767.1, XP_054223352.1, XP_054223353.1, NP_005684.2, XP_011518107.1, XP_005252764.1, XP_005252763.1, XP_005252762.1, XP_006718176.1, XP_006718175.1, XP_006718179.1, XP_006718178.1, XP_054223355.1, XP_054223350.1, XP_054223356.1, XP_054223357.1, XP_047282149.1, XP_024304066.1, XP_054223351.1, XP_047282151.1, XP_016872547.1, XP_047282153.1, XP_047282154.1, XP_047282156.1, XP_047282155.1, XP_047282157.1, XP_054223344.1, XP_054223345.1, NP_001123574.1, XP_054223346.1, XP_054223347.1, NP_001123573.1

Guide to Pharmacology - Targets

602

OpenTargets

ENSG00000025434

ENSEMBL

ENST00000441012, ENSG00000025434, ENSP00000420656, ENSP00000378793, ENST00000405853, ENST00000395397, ENSP00000384745, ENST00000467728, ENST00000407404, ENSP00000385801, ENSP00000387946

ZINC - Substances

NR1H3_HUMAN

ZINC - Biogenic

NR1H3_HUMAN

ZINC target

Q13133

PRO

Q13133

GlyGen

Q13133

PDB

1UHL, 5AVL, 3IPU, 5AVI, 3IPQ, 3IPS, 5HJS

ZINC - Metabolites

NR1H3_HUMAN

HPA

ENSG00000025434-NR1H3

GeneCards

NR1H3

Pharos - Targets

Q13133

ZINC - Predictions - Purchasable

NR1H3_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.742	7
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.691	15
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.666	4
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.642	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.611	5
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.609	8
UniProt:O60869 EDF1			0.581	4
UniProt:Q99750 MDFI			0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

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