Demethylase KDM1A binds KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625849
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Demethylase KDM1A binds KLK2 and KLK3 promoters
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PKN1-mediated phosphorylation of histone H3 threonine residue 12 (also labeled in literature as Thr11) enables recruitment of KDM1A (LSD1) demethylase to AR-regulated promoters KLK2 and KLK3 (PSA) (Metzger et al. 2008).

Literature References
PubMed ID Title Journal Year
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Kunowska, N, Patnaik, D, Schüle, R, Metzger, E, Wissmann, M, Potier, N, Scheidtmann, KH, Higgins, JM, Friedrichs, N, Buettner, R, Fischer, K, Yin, N

Nat. Cell Biol. 2008
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Orthologous Events
Demethylase KDM1A binds KLK2 and KLK3 promoters (Caenorhabditis elegans)
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Demethylase KDM1A binds KLK2 and KLK3 promoters (Drosophila melanogaster)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Gallus gallus)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Mus musculus)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-08)
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