Reactome | DYNLL2 [ciliary tip]

DYNLL2 [ciliary tip]

Stable Identifier

R-HSA-5625337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

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External Reference Information

External Reference

UniProt:Q96FJ2 DYNLL2

Gene Names

DYNLL2, DLC2

Chain

chain:1-89

Reference Genes

BioGPS Gene:140735 DYNLL2

COSMIC (genes):DYNLL2 DYNLL2

CTD Gene:140735 DYNLL2

dbSNP Gene:140735 DYNLL2

ENSEMBL:ENSG00000264364 DYNLL2

ENSEMBL_homo_sapiens_GENE:ENSG00000264364.3 DYNLL2

HGNC:24596 DYNLL2

KEGG Gene (Homo sapiens):140735 DYNLL2

Monarch:140735 DYNLL2

NCBI Gene:140735 DYNLL2

OMIM:608942 DYNLL2

UCSC:Q96FJ2 DYNLL2

Reference Transcript

RefSeq:NM_080677.2 DYNLL2

Other Identifiers

11735011_at

11735012_a_at

140735

16836404

225494_PM_at

225494_at

229106_PM_at

229106_at

238467_PM_at

238467_at

3728514

3728515

3728516

3728521

3728523

3728524

3728525

3728526

3728527

3728528

3728538

3728540

3728541

3728542

3728544

3728546

3728547

3728548

3728549

3728550

3728551

3728553

3728555

3728556

3728558

3728559

3728561

43071_at

44688_at

46139_at

51938_at

67193_at

8008706

81961_at

A_23_P54991

A_24_P125311

GE54745

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0007017

GO:0015630

GO:0016020

GO:0030286

GO:0031475

GO:0043226

GO:0045505

GO:0097542

GO:0097731

GO:0098794

GO:0098978

HMNXSV003032208

HMNXSV003058334

Hs.127121.0.A1_3p_at

Hs.7811.1.A1_3p_a_at

Hs.7811.1.A1_3p_x_at

ILMN_1772796

PH_hs_0026640

TC17000707.hg

p7442

Participates

as a member of

dynein-2 light chains [ciliary tip] (Homo sapiens)

Other forms of this molecule

DYNLL2 [cytosol]

DYNLL2 [plasma membrane]

DYNLL2 [cilium]

Inferred To

dlc-1 [ciliary tip] (Caenorhabditis elegans)

DYNLL2 [ciliary tip] (Bos taurus)

DYNLL2 [ciliary tip] (Canis familiaris)

DYNLL2 [ciliary tip] (Gallus gallus)

DYNLL2 [ciliary tip] (Sus scrofa)

Dynll2 [ciliary tip] (Mus musculus)

Dynll2 [ciliary tip] (Rattus norvegicus)

Cross References

RefSeq

NP_542408.1

OpenTargets

ENSG00000264364

HPA

ENSG00000264364-DYNLL2

GeneCards

Q96FJ2

Ensembl

ENSP00000477310, ENSG00000264364, ENST00000579991

PRO

Q96FJ2

Pharos - Targets

Q96FJ2

PDB

7CNU, 2XQQ, 3P8M, 4D07

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.846	6
UniProt:O96015 DNAL4	1	DNAL4 [plasma membrane] (R-HSA-177484)	0.801	8
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.725	4
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.725	4
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.643	3
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.638	3
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.638	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.615	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	3
UniProt:Q96LC9 BMF	3	p-BMF [mitochondrial outer membrane] (R-HSA-3145026) BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529)	0.556	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q14678 KANK1	3	KANK1 [nucleoplasm] (R-HSA-9018640) p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593)	0.527	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q6PGQ7 BORA	3	p-S252-BORA [cytosol] (R-HSA-4086411) p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607)	0.527	2
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.527	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.527	2
UniProt:P46937 YAP1	7	p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.527	2
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.527	2
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.527	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	2
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	2
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.527	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.508	2

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