Reactome | KDM1A is recruited to MYC and BCL2 genes

KDM1A is recruited to MYC and BCL2 genes

Stable Identifier

R-HSA-9011984

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KDM1A is recruited to MYC and BCL2 genes

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Histone demethylase KDM1A (also known as LSD1) is recruited to estrogen-responsive promoters and enhancers in a manner that depends on the HAR domain of HIST1H2AC. KDM1A removes the repressive H3K9me2 epigenetic mark, and consistent with this, KDM1A knockdown leads to abrogated expression of BCL2 and MYC genes in response to estrogen stimulation (Perillo et al, 2008; Su et al, 2014; Wang et al, 2009; Wissmann et al, 2007)

Literature References

PubMed ID	Title	Journal	Year
18187655	DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression Ombra, MN, Sacchetti, S, Perillo, B, Chiariotti, L, Sasso, A, Avvedimento, EV, Abbondanza, C, Cuozzo, C, Malorni, A, Bertoni, A	Science	2008
17277772	Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression Vogler, C, Jenuwein, T, Schüle, R, Metzger, E, Greschik, H, Müller, JM, Wissmann, M, Schneider, R, Buettner, R, Fodor, BD, Günther, T, Yin, N	Nat. Cell Biol.	2007
19098913	The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation Sun, W, Kurash, JK, Gaudet, F, Xu, G, Gay, F, Chang, H, Li, E, Wang, J, Chen, T, Bajko, J, Su, H, Lei, H, Hevi, S	Nat. Genet.	2009
24371278	An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells Hsu, MT, Tzeng, TY, Cheng, C, Su, CH	Nucleic Acids Res.	2014