Reactome | DYNLL2 [plasma membrane]

DYNLL2 [plasma membrane]

Stable Identifier

R-HSA-140527

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

DLC2

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External Reference Information

External Reference

UniProt:Q96FJ2 DYNLL2

Gene Names

DYNLL2, DLC2

Chain

chain:1-89

Reference Genes

BioGPS Gene:140735 DYNLL2

COSMIC (genes):DYNLL2 DYNLL2

CTD Gene:140735 DYNLL2

dbSNP Gene:140735 DYNLL2

ENSEMBL:ENSG00000264364 DYNLL2

HGNC:24596 DYNLL2

KEGG:hsa:140735 DYNLL2

Monarch:140735 DYNLL2

NCBI Entrez Gene:140735 DYNLL2

OMIM:608942 DYNLL2

UCSC:Q96FJ2 DYNLL2

Reference Transcript

RefSeq:NM_080677.3 DYNLL2

Other Identifiers

11735011_at

11735012_a_at

140735

16836404

225494_PM_at

225494_at

229106_PM_at

229106_at

238467_PM_at

238467_at

3728514

3728515

3728516

3728517

3728518

3728519

3728520

3728521

3728523

3728524

3728525

3728526

3728527

3728528

3728534

3728536

3728538

3728540

3728541

3728542

3728544

3728546

3728547

3728548

3728549

3728550

3728551

3728553

3728555

3728556

3728558

3728559

3728561

43071_at

44688_at

46139_at

51938_at

67193_at

8008706

81961_at

A_14_P108787

A_23_P54991

A_24_P125311

GE54745

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0007017

GO:0014069

GO:0015630

GO:0016020

GO:0030286

GO:0031475

GO:0042802

GO:0043226

GO:0044877

GO:0045505

GO:0097110

GO:0097542

GO:0097731

GO:0098794

GO:0098978

HMNXSV003032208

HMNXSV003058334

Hs.127121.0.A1_3p_at

Hs.7811.1.A1_3p_a_at

Hs.7811.1.A1_3p_x_at

Hs.7811.2.A1_3p_at

ILMN_1772796

PH_hs_0026640

TC17000707.hg

p7442

Participates

as a component of

Other forms of this molecule

DYNLL2 [cytosol]

DYNLL2 [cilium]

DYNLL2 [ciliary tip]

Inferred To

DYNLL2 [plasma membrane] (Bos taurus)

DYNLL2 [plasma membrane] (Canis familiaris)

DYNLL2 [plasma membrane] (Gallus gallus)

DYNLL2 [plasma membrane] (Sus scrofa)

dynll2b [plasma membrane] (Danio rerio)

Dynll2 [plasma membrane] (Mus musculus)

Dynll2 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_542408.1

OpenTargets

ENSG00000264364

ENSEMBL

ENSG00000264364, ENSP00000477310, ENST00000579991

HPA

ENSG00000264364-DYNLL2

GeneCards

DYNLL2

PRO

Q96FJ2

Pharos - Targets

Q96FJ2

GlyGen

Q96FJ2

PDB

3P8M, 2XQQ, 4D07, 7CNU

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.846	6
UniProt:O96015 DNAL4	1	DNAL4 [plasma membrane] (R-HSA-177484)	0.801	8
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.788	5
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.725	4
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.725	4
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.725	4
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.706	4
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.643	3
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.643	3
UniProt:Q9UBW7 ZMYM2	7	ZMYM2 [nucleoplasm] (R-HSA-9930820) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.643	3
UniProt:Q14678 KANK1	3	KANK1 [nucleoplasm] (R-HSA-9018640) p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673890) KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane] (R-HSA-9673593)	0.643	3
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.643	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.643	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.643	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.643	3
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.638	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	3
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2
UniProt:P48729 CSNK1A1	3	CSNK1A1 [nucleoplasm] (R-HSA-9943726) CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2
UniProt:P29475 NOS1	1	NOS1 [cytosol] (R-HSA-419293)	0.527	2
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.527	2
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.527	2
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.527	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q6PGQ7 BORA	3	p-7S,2T-BORA [cytosol] (R-HSA-4086411) p-8S,3T-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607)	0.527	2
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.527	2
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.527	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:Q14677 CLINT1	1	p-CLINT1 [cytosol] (R-HSA-429811)	0.508	2

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