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EHMT2 [nucleoplasm]
Stable Identifier
R-HSA-212151
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G9a, Histone Methyltransferase G9a, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, KMT1C
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Ub-EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)
EHMT1,2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
Expression and translocation of olfactory receptors (Homo sapiens)
Expression of Olfactory Receptor (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96KQ7 EHMT2
Gene Names
EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36
Chain
initiator methionine:, chain:2-1210
Reference Genes
COSMIC (genes):EHMT2 EHMT2
dbSNP Gene:10919 EHMT2
ENSEMBL:ENSG00000204371 EHMT2
Participates
as a member of
EHMT1,2 [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
as a component of
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
Ub-EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of EHMT2 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of EHMT2 [nucleoplasm]
(Gallus gallus)
EHMT2 [nucleoplasm]
(Bos taurus)
EHMT2 [nucleoplasm]
(Canis familiaris)
EHMT2 [nucleoplasm]
(Mus musculus)
EHMT2 [nucleoplasm]
(Sus scrofa)
ehmt2 [nucleoplasm]
(Xenopus tropicalis)
Ehmt2 [nucleoplasm]
(Rattus norvegicus)
G9a [nucleoplasm]
(Drosophila melanogaster)
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60568 PLOD3
1
PLOD3 [endoplasmic reticulum membrane]
(R-HSA-1981135)
0.831
8
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.794
9
UniProt:Q96JM2 ZN462
0.742
5
UniProt:Q9Y4X4 KLF12
0.739
5
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.725
4
UniProt:O95785 WIZ
0.725
4
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.69
8
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.677
7
UniProt:P57682 KLF3
0.659
4
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.643
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.643
3
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.612
20
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.612
18
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.577
9
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.577
6
UniProt:Q99801-1 NKX3-1
0.558
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.556
3
UniProt:Q96BV0 ZNF775
1
ZNF775 [nucleoplasm]
(R-HSA-3110230)
0.556
3
UniProt:Q7Z3Z2 RD3
0.556
3
UniProt:Q9UM22 EPDR1
0.556
3
UniProt:Q14119 VEZF1
0.556
3
UniProt:P20592 MX2
1
MX2 [cytosol]
(R-HSA-1015675)
0.556
3
UniProt:Q96EG3 ZN837
0.556
3
UniProt:Q96JB3 HIC2
0.556
3
UniProt:Q6VMQ6-2 ATF7IP
0.556
3
UniProt:Q9P2R6 RERE
0.556
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:Q9NWS9-2 ZNF446
0.556
3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4
0.556
3
UniProt:P84243 H3-3A
18
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
H3F3A [extracellular region]
(R-HSA-977567)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
Me1K5-H3-3A [nucleoplasm]
(R-HSA-9864864)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
0.547
2
UniProt:Q99IB8-PRO_0000045599
0.547
2
UniProt:Q96GT9 XAGE2
0.547
3
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.527
4
UniProt:Q9Y232 CDYL
0.527
2
UniProt:Q8N108 MIER1
0.527
2
UniProt:Q9H582 ZN644
0.527
2
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.524
3
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
3
UniProt:Q07120 GFI1
0.524
3
UniProt:Q5JSZ5 PRC2B
0.508
2
UniProt:O60341-1 KDM1A
0.499
2
UniProt:Q9NQX1 PRDM5
0.499
3
UniProt:O14646 CHD1
1
CHD1 [nucleoplasm]
(R-HSA-9012174)
0.499
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
UniProt:Q9NHX6 Gug
1
GUG [cytosol]
(R-DME-350975)
0.463
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.462
4
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.462
5
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