Reactome | BRK1 [cytosol]

BRK1

Stable Identifier

R-HSA-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HSPC300, Protein BRICK1, BRK1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - WAVE Regulatory Complex (WRC) interacts with RAC1 and PIP3 and gets activated (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - WAVE Regulatory Complex (WRC) interacts with RAC1 and PIP3 and gets activated (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases (Homo sapiens)
  - RHO GTPase Effectors (Homo sapiens)
    - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - WAVE Regulatory Complex (WRC) interacts with RAC1 and PIP3 and gets activated (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        BRK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUW1 BRK1

Gene Names

BRK1, C3orf10, HSPC300, MDS027

Chain

initiator methionine:1, chain:2-75

Reference Genes

BioGPS Gene:55845 BRK1

COSMIC (genes):BRK1 BRK1

CTD Gene:55845 BRK1

dbSNP Gene:55845 BRK1

ENSEMBL:ENSG00000254999 BRK1

HGNC:23057 BRK1

KEGG Gene (Homo sapiens):hsa:55845 BRK1

Monarch:55845 BRK1

NCBI Gene:55845 BRK1

OMIM:611183 BRK1

UCSC:Q8WUW1 BRK1

Reference Transcript

RefSeq:NM_018462.4 BRK1

Other Identifiers

0005360594

11715979_x_at

16937563

224575_at

2610318

2610319

2610321

2610322

2610323

3P8C

4N78

55845

56418_at

60391

8077770

A_23_P420361

A_24_P157342

AAF28978

AAH01067

AAH07929

AAH19303

AAN60161

AAN60162

AF161418

AK312155

AY148219

AY148220

BAG35089

BC001067

BC007929

BC019303

BRK1

BRK1-201

CCDS54553

CH471055

EAW64061

ENSG00000254999

ENSP00000432472

ENST00000530758

EntrezGene:55845

GE688143

GO:0001701

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0006810

GO:0007010

GO:0007015

GO:0007165

GO:0008150

GO:0008283

GO:0008284

GO:0009790

GO:0010592

GO:0016192

GO:0016601

GO:0019899

GO:0022607

GO:0030027

GO:0030036

GO:0031209

GO:0032991

GO:0038096

GO:0040011

GO:0043226

GO:0044877

GO:0048010

GO:0048365

GO:0048856

GO:0048870

GO:0065003

GO:0070062

GO:0070207

GO:2000601

HGNC:23057

HPA060391

Hs.273369.2.S1_3p_at

ILMN_1764500

IPR033378

MIM:611183

NM_018462

NP_060932

PH_hs_0019746

PH_hs_0035943

PH_hs_0037792

TC03000053.hg

uc003bvb.4

UPI0000049C9A

Participant Of

hasComponent

Inferred To

Ghost homologue of BRK1 [cytosol] (Bos taurus)

Ghost homologue of BRK1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of BRK1 [cytosol] (Sus scrofa)

Ghost homologue of BRK1 [cytosol] (Taeniopygia guttata)

BRK1 [cytosol] (Canis familiaris)

BRK1 [cytosol] (Danio rerio)

BRK1 [cytosol] (Dictyostelium discoideum)

BRK1 [cytosol] (Drosophila melanogaster)

BRK1 [cytosol] (Gallus gallus)

BRK1 [cytosol] (Mus musculus)

BRK1 [cytosol] (Rattus norvegicus)

BRK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_060932.2

GeneCards

Q8WUW1

PRO

Q8WUW1

PDB

4N78, 3P8C

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.556	3