Reactome | EXOC5 [cytosol]

EXOC5 [cytosol]

Stable Identifier

R-HSA-265045

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00471 EXOC5

Gene Names

EXOC5, SEC10, SEC10L1

Chain

initiator methionine:1, chain:2-708

Reference Genes

BioGPS Gene:10640 EXOC5

COSMIC (genes):EXOC5 EXOC5

CTD Gene:10640 EXOC5

dbSNP Gene:10640 EXOC5

ENSEMBL:ENSG00000070367 EXOC5

HGNC:10696 EXOC5

KEGG Gene (Homo sapiens):10640 EXOC5

Monarch:10640 EXOC5

NCBI Gene:10640 EXOC5

OMIM:604469 EXOC5

UCSC:O00471 EXOC5

Reference Transcript

RefSeq:NM_006544.3 EXOC5

Other Identifiers

0000940025

10640

11719456_at

11719457_s_at

11719458_at

11719459_at

11749681_a_at

11749682_s_at

11757786_s_at

16793353

218748_s_at

222726_3p_s_at

222726_s_at

225084_at

228418_at

2729215

2729216

2729217

2729222

3566301

3566303

3566305

3566306

3566307

3566308

3566310

3566311

3566312

3566315

3566316

3566318

3566320

3566321

3566324

3566328

3566329

3566331

3566333

3566334

3566342

3566343

3566344

3566345

3566351

3566352

45744_at

57159_at

7979367

8095333

88639_at

A_23_P14464

A_24_P224219

A_24_P256830

A_32_P172755

GE78968

GO:0000145

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006810

GO:0006887

GO:0006892

GO:0006893

GO:0008150

GO:0015031

GO:0016192

GO:0017160

GO:0019899

GO:0030496

GO:0032991

GO:0047485

GO:0072659

Hs.279947.0.S2_3p_s_at

Hs.29494.1.S1_3p_at

Hs.29494.2.S1_3p_at

Hs.29494.2.S1_3p_x_at

ILMN_1788625

PH_hs_0029885

TC14001170.hg

U85946_at

g5730036_3p_a_at

Participant Of

hasComponent

Exocyst Complex [plasma membrane]

input

Exocyst complex formation

Other forms of this molecule

EXOC5 [cytosol]

Inferred To

sec10 [cytosol] (Schizosaccharomyces pombe)

EXOC5 [cytosol] (Canis familiaris)

EXOC5 [cytosol] (Gallus gallus)

EXOC5 [cytosol] (Sus scrofa)

Sec10 [cytosol] (Drosophila melanogaster)

Exoc5 [cytosol] (Mus musculus)

Exoc5 [cytosol] (Rattus norvegicus)

sec-10 [cytosol] (Caenorhabditis elegans)

exoc5 [cytosol] (Danio rerio)

exoc5 [cytosol] (Dictyostelium discoideum)

SEC10 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_006535.1

OpenTargets

ENSG00000070367

HPA

ENSG00000070367-EXOC5

GeneCards

O00471

Ensembl

ENSP00000484855, ENST00000621441, ENSG00000070367

PRO

O00471

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAG9 EXOC6	2	EXOC6 [cytosol] (R-HSA-5623384) EXOC6 [plasma membrane] (R-HSA-265041)	0.793	7
UniProt:Q9Y2D4 EXC6B			0.731	7
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.718	6
UniProt:P00973-2 OAS1			0.718	6
UniProt:Q05D60 DEUP1			0.718	11
UniProt:P61106 RAB14	7	GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.718	6
UniProt:P43360 MAGA6			0.718	6
UniProt:P20338 RAB4A	5	GGC-RAB4A [cytosol] (R-HSA-8874045) GGC-RAB4A [cytoplasmic vesicle membrane] (R-HSA-1458526) RAB4A [cytosol] (R-HSA-8873709) RAB4A [early endosome membrane] (R-HSA-8871356) GGC-RAB4A [recycling endosome membrane] (R-HSA-8875666)	0.718	6
UniProt:P61018 RAB4B	5	RAB4B [cytosol] (R-HSA-8873680) GGC-RAB4B [cytosol] (R-HSA-8874049) RAB4B [plasma membrane] (R-HSA-6804989) RAB4B [secretory granule membrane] (R-HSA-6804976) GGC-RAB4B [recycling endosome membrane] (R-HSA-8875675)	0.718	6
UniProt:O14787 TNPO2			0.666	4
UniProt:Q8N3L3 TXLNB			0.666	4
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.638	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [cytosol] (R-HSA-5623388) EXOC8 [plasma membrane] (R-HSA-264948)	0.638	4
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.556	3
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:Q6PF05-3 TTC23L			0.556	3
UniProt:P00973 OAS1	1	OAS1 [cytosol] (R-HSA-947486)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9ULZ3 PYCARD	4	PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [cytosol] (R-HSA-561191) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.556	5
UniProt:Q99728 BARD1	13	BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 [nucleoplasm] (R-HSA-5659775) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q3B7T1-5 EDRF1			0.556	3
UniProt:A0A0S2Z4Q4 A0A0S2Z4Q4			0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:A0AVN2 A0AVN2			0.556	3
IntAct:EBI-16430217 CCSB ISOFORM ID			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.556	3
UniProt:P53674 CRBB1			0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:P43357 MAGA3			0.556	3
UniProt:Q96NE9 FRMD6			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q6FHV6 Q6FHV6			0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P02671-2 FGA			0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.556	3
UniProt:Q96E40 SACA9			0.556	3
UniProt:Q9BQD3 KXDL1			0.556	3
UniProt:Q8N4P3 MESH1			0.556	3
UniProt:A0A0S2Z528 A0A0S2Z528			0.556	3
UniProt:Q5PSV4 BRM1L			0.556	3
UniProt:P46459 NSF	1	NSF [cytosol] (R-HSA-264471)	0.508	2
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.508	3
UniProt:Q9UPT5 EXOC7	2	EXOC7 [cytosol] (R-HSA-5623386) EXOC7 [plasma membrane] (R-HSA-2872288)	0.508	3
UniProt:Q15051 IQCB1	1	IQCB1 [cytosol] (R-HSA-5626648)	0.508	2
UniProt:P61006 RAB8A	6	RAB8A [cytosol] (R-HSA-5623399) RAB8A [Golgi membrane] (R-HSA-2562535) GGC-RAB8A [cytosol] (R-HSA-8874063) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093)	0.508	2
UniProt:O15014 ZN609			0.508	2
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.508	2
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.508	2
UniProt:Q9NV70 EXOC1	2	EXOC1 [cytosol] (R-HSA-5623375) EXOC1 [plasma membrane] (R-HSA-2872284)	0.508	3

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