Reactome | FTL [azurophil granule lumen]

FTL [azurophil granule lumen]

Stable Identifier

R-HSA-6799149

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Ferritin light chain, FRIL_HUMAN

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External Reference Information

External Reference

UniProt:P02792 FTL

Gene Names

FTL

Chain

initiator methionine:, chain:2-175

Reference Genes

BioGPS Gene:2512 FTL

COSMIC (genes):FTL FTL

CTD Gene:2512 FTL

dbSNP Gene:2512 FTL

ENSEMBL:ENSG00000087086 FTL

HGNC:3999 FTL

KEGG:hsa:2512 FTL

Monarch:2512 FTL

NCBI Gene:2512 FTL

OMIM:134790 FTL

UCSC:P02792 FTL

Reference Transcript

RefSeq:NM_000146.3 FTL

Other Identifiers

11755280_x_at

11757269_s_at

11757326_s_at

11757327_x_at

11757346_s_at

11757728_s_at

11757787_x_at

11758182_x_at

16863939

212788_PM_x_at

212788_x_at

213187_PM_x_at

213187_x_at

2512

35083_at

3838095

3838096

3838097

3838099

3838102

3838103

3838104

3838105

3838106

3838107

3838108

3838110

3874609

3874610

3874611

3972940

43423_s_at

8030171

A_14_P128048

A_23_P50498

A_23_P50504

GO:0005506

GO:0005515

GO:0005576

GO:0005737

GO:0005764

GO:0005773

GO:0005776

GO:0005829

GO:0006826

GO:0006879

GO:0008198

GO:0008199

GO:0016020

GO:0031410

GO:0035578

GO:0042802

GO:0043226

GO:0044754

GO:0046872

GO:0070062

GO:0070288

HMNXSV003057940

Hs.111334.1.S1_3p_a_at

Hs.324746.2.S1_3p_s_at

ILMN_1740429

ILMN_1814823

M11147_at

TC19000717.hg

TC19002195.hg

TC20000047.hg

g7662555_3p_x_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

FTL [cytosol]

FTL [extracellular region]

FTL [endocytic vesicle lumen]

Inferred To

Fer2LCH [azurophil granule lumen] (Drosophila melanogaster)

Homologues of FTL [azurophil granule lumen] (Caenorhabditis elegans)

Homologues of FTL [azurophil granule lumen] (Danio rerio)

Homologues of FTL [azurophil granule lumen] (Drosophila melanogaster)

Homologues of FTL [azurophil granule lumen] (Rattus norvegicus)

fthl27 [azurophil granule lumen] (Danio rerio)

ftn-1 [azurophil granule lumen] (Caenorhabditis elegans)

FTL [azurophil granule lumen] (Bos taurus)

FTL [azurophil granule lumen] (Canis familiaris)

FTL [azurophil granule lumen] (Mus musculus)

FTL [azurophil granule lumen] (Sus scrofa)

Fer3HCH [azurophil granule lumen] (Drosophila melanogaster)

ftn-2 [azurophil granule lumen] (Caenorhabditis elegans)

Fer1HCH [azurophil granule lumen] (Drosophila melanogaster)

MGC75752 [azurophil granule lumen] (Xenopus tropicalis)

fthl28 [azurophil granule lumen] (Danio rerio)

fthl31 [azurophil granule lumen] (Danio rerio)

Ftl1 [azurophil granule lumen] (Rattus norvegicus)

Ftl1l2 [azurophil granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_000137.2

OpenTargets

ENSG00000087086

ENSEMBL

ENSG00000087086, ENSP00000366525, ENST00000331825

HPA

ENSG00000087086-FTL

GeneCards

FTL

PRO

P02792

Pharos - Targets

P02792

Orphanet

FTL

HMDB Protein

HMDBP02077

PDB

2FG4, 2FFX, 2FG8, 6TR9, 5LG8, 6TSF, 6TSA, 6TSJ, 4V6B, 6TS1, 3KXU, 6TS0, 6WX6

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.782	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	20
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q9UI43 MRM2	1	FTSJ2 [mitochondrial matrix] (R-HSA-6793061)	0.527	3
UniProt:P48730 CSNK1D	3	CSNK1D [cytosol] (R-HSA-380315) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [nucleoplasm] (R-HSA-421305)	0.527	3
UniProt:Q7L590 MCM10	1	MCM10 [nucleoplasm] (R-HSA-68403)	0.527	3
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.527	2
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.527	2
UniProt:Q9UJK0 TSR3	1	TSR3 [cytosol] (R-HSA-8868776)	0.527	3
UniProt:O95248 SBF1	2	SBF1 [cytosol] (R-HSA-8876843) SBF1 [endoplasmic reticulum membrane] (R-HSA-6809747)	0.527	3
UniProt:Q9BYK8 HELZ2	1	HELZ2 [nucleoplasm] (R-HSA-442499)	0.527	3
UniProt:Q5SQI0 ATAT1	1	ATAT [cytosol] (R-HSA-5618184)	0.527	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.527	2
UniProt:O43303 CCP110	2	CCP110 [cytosol] (R-HSA-380261) PolyUb-CCP110 [cytosol] (R-HSA-6783044)	0.527	3
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	2
UniProt:Q8IXZ2 ZC3H3	1	ZC3H3 [nucleoplasm] (R-HSA-9933572)	0.527	3
UniProt:Q6P0N0 MIS18BP1	2	MIS18BP1 [nucleoplasm] (R-HSA-606300) p-T653-MIS18BP1 [nucleoplasm] (R-HSA-9929905)	0.527	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.527	2
UniProt:Q9NYY8 FASTKD2	1	FASTKD2 [mitochondrial matrix] (R-HSA-9837146)	0.527	3
UniProt:O14733 MAP2K7	4	p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353) MAP2K7 [cytosol] (R-HSA-450276) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401)	0.527	3
UniProt:Q8WVC6 DCAKD	1	DCAKD [mitochondrial outer membrane] (R-HSA-9837353)	0.527	3
UniProt:Q7Z6M1 RABEPK	3	pS-RABEPK [transport vesicle] (R-HSA-8847851) RABEPK [cytosol] (R-HSA-8847841) pS-RABEPK [trans-Golgi network membrane] (R-HSA-8847849)	0.527	2
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.508	3

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