Reactome | ELL2 [nucleoplasm]

ELL2 [nucleoplasm]

Stable Identifier

R-HSA-6807506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RNA polymerase II elongation factor ELL2, ELL2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)
        
        ELL2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00472 ELL2

Gene Names

ELL2

Chain

chain:1-640

Reference Genes

BioGPS Gene:22936 ELL2

COSMIC (genes):ELL2 ELL2

CTD Gene:22936 ELL2

dbSNP Gene:22936 ELL2

ENSEMBL:ENSG00000118985 ELL2

ENSEMBL_homo_sapiens_GENE:ENSG00000118985.16 ELL2

HGNC:17064 ELL2

KEGG Gene (Homo sapiens):22936 ELL2

Monarch:22936 ELL2

NCBI Gene:22936 ELL2

OMIM:601874 ELL2

UCSC:O00472 ELL2

Reference Transcript

RefSeq:NM_012081.5 ELL2

Other Identifiers

11736477_a_at

11736478_a_at

11749208_a_at

11752840_a_at

11755239_a_at

148_at

16998309

214446_PM_at

214446_at

226099_PM_at

226099_at

226982_PM_at

226982_at

22936

2439245

2439248

2439257

2439258

2439262

2867874

2867875

2867876

2867877

2867879

2867882

2867887

2867888

2867891

2867894

2867895

2867902

2867914

2867917

2867935

2867951

2867952

2867953

2867954

40606_at

46169_at

53313_at

62502_at

7921344

8113220

A_23_P251011

A_23_P41645

A_23_P58506

GE81750

GE86859

GO:0000987

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006366

GO:0006368

GO:0008023

GO:0016073

GO:0032968

GO:0042795

GO:0043226

HMNXSV003006330

HMNXSV003057953

Hs.173334.0.A1_3p_at

Hs.173334.1.A1_3p_at

Hs.173334.2.S1_3p_at

ILMN_1655930

PH_hs_0029396

TC05001610.hg

U88629_at

Participates

as a member of

ELL,ELL2,ELL3 [nucleoplasm] (Homo sapiens)

Inferred To

Ell [nucleoplasm] (Drosophila melanogaster)

ell2 [nucleoplasm] (Xenopus tropicalis)

Ell2 [nucleoplasm] (Mus musculus)

Ell2 [nucleoplasm] (Rattus norvegicus)

ell-1 [nucleoplasm] (Caenorhabditis elegans)

ELL2 [nucleoplasm] (Bos taurus)

ELL2 [nucleoplasm] (Canis familiaris)

ELL2 [nucleoplasm] (Gallus gallus)

ELL2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_036213.2

OpenTargets

ENSG00000118985

HPA

ENSG00000118985-ELL2

GeneCards

O00472

Ensembl

ENSP00000237853, ENST00000237853, ENSG00000118985

PRO

O00472

Pharos - Targets

O00472

PDB

7OKX, 2E5N, 7OKY, 5JW9

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.8	9
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.725	6
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.643	4
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.527	3
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4