Reactome | TWIST2 [nucleoplasm]

TWIST2 [nucleoplasm]

Stable Identifier

R-HSA-445444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Twist-related protein 2, TWST2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8WVJ9 TWIST2

Gene Names

TWIST2, BHLHA39, DERMO1

Chain

chain:1-160

Reference Genes

BioGPS Gene:117581 TWIST2

COSMIC (genes):TWIST2 TWIST2

CTD Gene:117581 TWIST2

dbSNP Gene:117581 TWIST2

ENSEMBL:ENSG00000233608 TWIST2

HGNC:20670 TWIST2

KEGG:hsa:117581 TWIST2

Monarch:117581 TWIST2

NCBI Gene:117581 TWIST2

OMIM:607556 TWIST2

UCSC:Q8WVJ9 TWIST2

Reference Transcript

Other Identifiers

11757853_s_at

117581

11759871_at

1554163_PM_at

1554163_at

16893143

229404_PM_at

229404_at

2535028

4104733

44596_at

8180300

A_19_P00322910

A_19_P00322911

A_19_P00809039

GE88844

GO:0000977

GO:0000981

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006355

GO:0006357

GO:0030154

GO:0030335

GO:0032502

GO:0043226

GO:0045668

GO:0045892

GO:0046983

GO:0140110

HMNXSV003043936

Hs.32366.0.A1_3p_at

Hs2.32366.2.S1_3p_at

ILMN_1677429

ILMN_1721383

PH_hs_0025157

PH_hs_0033274

PH_hs_0036496

TC02001458.hg

Participates

as an input of

TWIST2 binds CDH1 gene promoter (Homo sapiens)

as a component of

TWIST2:CDH1 gene [nucleoplasm] (Homo sapiens)

as a member of

TWIST1,TWIST2 [nucleoplasm] (Homo sapiens)

Inferred To

twi [nucleoplasm] (Drosophila melanogaster)

TWIST2 [nucleoplasm] (Bos taurus)

TWIST2 [nucleoplasm] (Canis familiaris)

TWIST2 [nucleoplasm] (Sus scrofa)

Twist2 [nucleoplasm] (Mus musculus)

Twist2 [nucleoplasm] (Rattus norvegicus)

twist2 [nucleoplasm] (Danio rerio)

cdermo-1 [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_001258822.1, NP_476527.1

OpenTargets

ENSG00000233608

ENSEMBL

ENSP00000518373, ENSP00000518374, ENSP00000482581, ENST00000710608, ENST00000710607, ENSP00000500609, ENST00000673387, ENSG00000288335, ENST00000671947, ENST00000612363, ENSG00000233608, ENSP00000500440, ENST00000448943, ENSP00000405176

HPA

ENSG00000233608-TWIST2

GeneCards

TWIST2

PRO

Q8WVJ9

Pharos - Targets

Q8WVJ9

Orphanet

TWIST2

GlyGen

Q8WVJ9

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.742	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	5
UniProt:Q9BSQ5 CCM2			0.57	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:Q9BZE0 GLIS2			0.556	3
UniProt:P54253 ATX1			0.556	6
UniProt:P01023 A2M	2	A2M [platelet alpha granule lumen] (R-HSA-139834) A2M [extracellular region] (R-HSA-49291)	0.556	3
UniProt:Q99081-3 TCF12			0.556	3
IntAct:EBI-22318930 CCSB ORF ID			0.556	5
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:P15923-3 TCF3			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.524	2