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TWIST2 [nucleoplasm]
Stable Identifier
R-HSA-445444
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Twist-related protein 2, TWST2_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Gene Transcription (Homo sapiens)
Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
TWIST2 binds CDH1 gene promoter (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
TWIST2:CDH1 gene [nucleoplasm] (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
TWIST2 represses CDH1 gene transcription (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
TWIST2:CDH1 gene [nucleoplasm] (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 binds TWIST1,(TWIST2) (Homo sapiens)
RUNX2:TWIST1,TWIST2 [nucleoplasm] (Homo sapiens)
TWIST1,TWIST2 [nucleoplasm] (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
TWIST1,TWIST2 [nucleoplasm] (Homo sapiens)
TWIST2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WVJ9 TWIST2
Gene Names
TWIST2, BHLHA39, DERMO1
Chain
chain:1-160
Reference Genes
BioGPS Gene:117581 TWIST2
COSMIC (genes):TWIST2 TWIST2
CTD Gene:117581 TWIST2
dbSNP Gene:117581 TWIST2
ENSEMBL:ENSG00000233608 TWIST2
HGNC:20670 TWIST2
KEGG:hsa:117581 TWIST2
Monarch:117581 TWIST2
NCBI Gene:117581 TWIST2
OMIM:607556 TWIST2
UCSC:Q8WVJ9 TWIST2
Reference Transcript
RefSeq:NM_001271893.4 TWIST2
RefSeq:NM_057179.3 TWIST2
Other Identifiers
11757853_s_at
117581
11759871_at
1554163_PM_at
1554163_at
16893143
229404_PM_at
229404_at
2535028
4104733
44596_at
8180300
A_19_P00322910
A_19_P00322911
A_19_P00809039
GE88844
GO:0000977
GO:0000981
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006355
GO:0006357
GO:0030154
GO:0030335
GO:0032502
GO:0043226
GO:0045668
GO:0045892
GO:0046983
GO:0140110
HMNXSV003043936
Hs.32366.0.A1_3p_at
Hs2.32366.2.S1_3p_at
ILMN_1677429
ILMN_1721383
PH_hs_0025157
PH_hs_0033274
PH_hs_0036496
TC02001458.hg
Participates
as an input of
TWIST2 binds CDH1 gene promoter (Homo sapiens)
as a component of
TWIST2:CDH1 gene [nucleoplasm] (Homo sapiens)
as a member of
TWIST1,TWIST2 [nucleoplasm] (Homo sapiens)
Inferred To
twi [nucleoplasm]
(Drosophila melanogaster)
TWIST2 [nucleoplasm]
(Bos taurus)
TWIST2 [nucleoplasm]
(Canis familiaris)
TWIST2 [nucleoplasm]
(Sus scrofa)
Twist2 [nucleoplasm]
(Mus musculus)
Twist2 [nucleoplasm]
(Rattus norvegicus)
twist2 [nucleoplasm]
(Danio rerio)
cdermo-1 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_001258822.1
,
NP_476527.1
OpenTargets
ENSG00000233608
ENSEMBL
ENSP00000518373
,
ENSP00000518374
,
ENSP00000482581
,
ENST00000710608
,
ENST00000710607
,
ENSP00000500609
,
ENST00000673387
,
ENSG00000288335
,
ENST00000671947
,
ENST00000612363
,
ENSG00000233608
,
ENSP00000500440
,
ENST00000448943
,
ENSP00000405176
HPA
ENSG00000233608-TWIST2
GeneCards
TWIST2
PRO
Q8WVJ9
Pharos - Targets
Q8WVJ9
Orphanet
TWIST2
GlyGen
Q8WVJ9
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.742
5
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.666
5
UniProt:Q9BSQ5 CCM2
0.57
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
IntAct:EBI-25865403 EHD27213144
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:Q9BZE0 GLIS2
0.556
3
UniProt:P54253 ATX1
0.556
6
UniProt:P01023 A2M
2
A2M [platelet alpha granule lumen]
(R-HSA-139834)
A2M [extracellular region]
(R-HSA-49291)
0.556
3
UniProt:Q99081-3 TCF12
0.556
3
IntAct:EBI-22318930 CCSB ORF ID
0.556
5
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:P15923-3 TCF3
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P15036 ETS2
2
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
ETS2 [nucleoplasm]
(R-HSA-1629811)
0.524
2
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