Reactome | polySUMO2,3-K330-TDG [nucleoplasm]

polySUMO2,3-K330-TDG [nucleoplasm]

Stable Identifier

R-HSA-4551628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
11889051	Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover Steinacher, R, Hardeland, U, Schär, P, Jiricny, J	EMBO J.	2002
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
16626738	Crystal structure of SUMO-3-modified thymine-DNA glycosylase Shirakawa, M, Baba, D, Hiroaki, H, Maita, N, Tochio, H, Uchimura, Y, Sugasawa, K, Hanaoka, F, Saitoh, H, Jee, JG	J. Mol. Biol.	2006
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014

External Reference Information

External Reference

UniProt:Q13569 TDG

Gene Names

TDG

Chain

chain:1-410

Reference Genes

BioGPS Gene:6996 TDG

COSMIC (genes):TDG TDG

CTD Gene:6996 TDG

dbSNP Gene:6996 TDG

ENSEMBL:ENSG00000139372 TDG

HGNC:11700 TDG

KEGG Gene (Homo sapiens):6996 TDG

Monarch:6996 TDG

NCBI Gene:6996 TDG

OMIM:601423 TDG

UCSC:Q13569 TDG

Reference Transcript

RefSeq:NM_003211.4 TDG

Other Identifiers

0000670433

11746509_a_at

11758036_s_at

16756111

203743_s_at

3373603

3408686

3408690

3408691

3408693

3408697

3429366

3429367

3429372

3429373

3429375

3429377

3429378

3429379

3429381

3429383

3429384

3429385

3429386

3429387

40865_at

6996

7958147

A_14_P110025

A_14_P138419

A_23_P204579

A_24_P526177

A_33_P3357445

GE81245

GO:0000122

GO:0000287

GO:0000700

GO:0003674

GO:0003677

GO:0003684

GO:0003690

GO:0004844

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005886

GO:0006259

GO:0006281

GO:0006284

GO:0006285

GO:0006287

GO:0006298

GO:0006325

GO:0006950

GO:0006974

GO:0008134

GO:0008150

GO:0008263

GO:0009056

GO:0009058

GO:0009790

GO:0016787

GO:0016798

GO:0019104

GO:0019904

GO:0030983

GO:0031402

GO:0031404

GO:0032182

GO:0032183

GO:0034641

GO:0034655

GO:0035511

GO:0040029

GO:0042803

GO:0043167

GO:0043226

GO:0043621

GO:0043739

GO:0044281

GO:0045008

GO:0045995

GO:0048856

GO:0051276

GO:0080111

GO:1902544

HMNXSV003003285

HMNXSV003007708

ILMN_1777096

ILMN_1782331

PH_hs_0030709

TC12000254.hg

TC12000804.hg

TC12002547.hg

U51166_at

g4507422_3p_a_at

Participates

as an output of

SUMOylation of TDG with SUMO2,3 (Homo sapiens)

Other forms of this molecule

TDG [nucleoplasm]

monoSUMO1-K330-TDG [nucleoplasm]

Inferred To

tdg.2 [nucleoplasm] (Danio rerio)

TDG [nucleoplasm] (Gallus gallus)

tdg [nucleoplasm] (Xenopus tropicalis)

Tdg [nucleoplasm] (Drosophila melanogaster)

Tdg [nucleoplasm] (Mus musculus)

Tdg [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 330

Coordinate

330

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_003202.3

OpenTargets

ENSG00000139372

IntEnz

3.2.2.29

GeneCards

Q13569

HPA

ENSG00000139372-TDG

Ensembl

ENST00000392872, ENSG00000139372, ENSP00000376611

PRO

Q13569

Pharos - Targets

Q13569

HMDB Protein

HMDBP09192

PDB

5HF7, 5CYS, 4Z3A, 4Z7Z, 5FF8, 3UFJ, 3UOB, 5JXY, 1WYW, 6U17, 4Z47, 4JGC, 2RBA, 4FNC, 2D07, 6U15, 4XEG, 6U16, 5T2W, 4Z7B, 3UO7

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.667	3
UniProt:Q9GZX7 AICDA			0.576	5
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.576	8
UniProt:P61956 SUMO2	5	SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.558	2
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.524	3
UniProt:PGR ENSG00000082175			0.499	2
UniProt:O88846	1	Rnf4 [cytosol] (R-RNO-975974)	0.499	2