Reactome | VAMP2(2-81) [cytosol]

VAMP2(2-81) [cytosol]

Stable Identifier

R-HSA-5250970

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

VAMP2 aminoterminal fragment

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Uptake and actions of bacterial toxins (Homo sapiens)
      - Neurotoxicity of clostridium toxins (Homo sapiens)
        
        Toxicity of botulinum toxin type G (botG) (Homo sapiens)
        
        botG LC cleaves target cell VAMP2 (Homo sapiens)
        
        VAMP2(2-81) [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
7910017	Botulinum neurotoxin type G proteolyses the Ala81-Ala82 bond of rat synaptobrevin 2 Hayashi, T, Yamasaki, S, Niemann, H, Eklund, M, Szabo, E, Binz, T, Jahn, R, Yamasaki, N	Biochem. Biophys. Res. Commun.	1994
8051110	Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond Malizio, C, Polverino de Laureto, P, Trimble, WS, Schiavo, G, Milan, G, Montecucco, C, Johnson, EA, Sugiyama, H	J. Biol. Chem.	1994

External Reference Information

External Reference

UniProt:P63027 VAMP2

Gene Names

VAMP2, SYB2

Chain

initiator methionine:, chain:2-116

Reference Genes

BioGPS Gene:6844 VAMP2

COSMIC (genes):VAMP2 VAMP2

CTD Gene:6844 VAMP2

dbSNP Gene:6844 VAMP2

ENSEMBL:ENSG00000220205 VAMP2

ENSEMBL_homo_sapiens_GENE:ENSG00000220205.10 VAMP2

HGNC:12643 VAMP2

KEGG Gene (Homo sapiens):6844 VAMP2

Monarch:6844 VAMP2

NCBI Gene:6844 VAMP2

OMIM:185881 VAMP2

UCSC:P63027 VAMP2

Reference Transcript

RefSeq:NM_014232.2 VAMP2

Other Identifiers

11716067_at

11716068_a_at

16840876

201556_PM_s_at

201556_s_at

201557_PM_at

201557_at

214792_PM_x_at

214792_x_at

32254_at

3744218

3744219

3744221

3744222

3744223

3744227

6844

8012376

A_23_P164341

A_24_P313576

A_33_P3213493

A_33_P3409886

GE62982

GO:0000149

GO:0002376

GO:0005484

GO:0005515

GO:0005516

GO:0005543

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006886

GO:0006887

GO:0006906

GO:0008021

GO:0008076

GO:0008289

GO:0009749

GO:0015031

GO:0016020

GO:0016079

GO:0016192

GO:0017075

GO:0017156

GO:0017157

GO:0019905

GO:0023052

GO:0030136

GO:0030141

GO:0030667

GO:0030669

GO:0030672

GO:0031201

GO:0031410

GO:0031982

GO:0032869

GO:0035493

GO:0042589

GO:0043001

GO:0043005

GO:0043226

GO:0043231

GO:0043308

GO:0044306

GO:0045202

GO:0048306

GO:0048471

GO:0048488

GO:0055085

GO:0060090

GO:0060203

GO:0060291

GO:0060627

GO:0061024

GO:0061025

GO:0061202

GO:0065003

GO:0070032

GO:0070033

GO:0070044

GO:0070083

GO:0072659

GO:0090316

GO:1902259

HMNXSV003039309

Hs.194534.1.A1_3p_a_at

Hs.194534.1.A1_3p_x_at

ILMN_1713491

ILMN_1911044

M36205_at

PH_hs_0002231

TC17002850.hg

g12803794_3p_a_at

g12803794_3p_x_at

g7657674_3p_at

g7657674_3p_x_at

Participates

as an output of

botG LC cleaves target cell VAMP2 (Homo sapiens)

Other forms of this molecule

VAMP2 [clathrin-coated endocytic vesicle membrane]

VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]

VAMP2 [plasma membrane]

VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]

VAMP2 [synaptic vesicle membrane]

VAMP2(59-116) [synaptic vesicle membrane]

VAMP2(2-58) [cytosol]

VAMP2(2-76) [cytosol]

VAMP2(77-116) [synaptic vesicle membrane]

VAMP2(60-116) [synaptic vesicle membrane]

VAMP2(2-59) [cytosol]

VAMP2(82-116) [synaptic vesicle membrane]

VAMP2 [secretory granule membrane]

VAMP2 [cytosol]

VAMP2 [endoplasmic reticulum membrane]

VAMP2 [cytoplasmic vesicle membrane]

VAMP2 [lysosomal membrane]

VAMP2 [Golgi membrane]

Disease

Name	Identifier	Synonyms
botulism	DOID:11976	Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning

Cross References

RefSeq

NP_055047.2

OpenTargets

ENSG00000220205

GeneCards

P63027

HPA

ENSG00000220205-VAMP2

Ensembl

ENSP00000314214, ENSG00000220205, ENST00000316509

PRO

P63027

Pharos - Targets

P63027

PDB

7UDC, 3FIE, 3RL0, 3FII, 3RK2, 3RK3

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60880-2 SNAP25			0.764	9
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.718	6
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.666	4
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.666	5
UniProt:P61266 STX1B	3	STX1B(1-?) [cytosol] (R-HSA-5246520) STX1B(?-288) [plasma membrane] (R-HSA-5246519) STX1B [plasma membrane] (R-HSA-181479)	0.659	4
UniProt:O14810 CPLX1	1	CPLX1 [cytosol] (R-HSA-210385)	0.656	3
UniProt:Q8IWB7 WDFY1			0.643	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.632	5
UniProt:O94806 PRKD3	1	PRKD3 [cytosol] (R-HSA-58212)	0.618	7
UniProt:Q57236 Q57236			0.558	3
UniProt:O55012	3	Picalm [Golgi membrane] (R-RNO-434341) Picalm [cytoplasmic vesicle membrane] (R-RNO-429812) Picalm [cytosol] (R-RNO-8867593)	0.558	2
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q5T0T0 MARH8			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q8TBB6 S7A14			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q9HA82 CERS4	1	CERS4 [endoplasmic reticulum membrane] (R-HSA-428138)	0.556	3
UniProt:Q96IK0 TM101			0.556	3
UniProt:P31937 HIBADH	1	HIBADH [mitochondrial matrix] (R-HSA-70882)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q3ZAQ7 VMA21			0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:O75558 STX11			0.527	2
UniProt:Q8N4C7 STX19			0.527	2
UniProt:Q86Y82 STX12			0.527	4
UniProt:Q16563 SYPL1			0.527	2
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.527	2

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