Reactome | LSM8 [nucleoplasm]

LSM8 [nucleoplasm]

Stable Identifier

R-HSA-6806779

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U6 snRNA-associated Sm-like protein LSm8, LSM8_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM8 [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95777 LSM8

Gene Names

LSM8

Chain

initiator methionine:1, chain:2-96

Reference Genes

BioGPS Gene:51691 LSM8

COSMIC (genes):LSM8 LSM8

CTD Gene:51691 LSM8

dbSNP Gene:51691 LSM8

ENSEMBL:ENSG00000128534 LSM8

ENSEMBL:ENSG00000128534.8 LSM8

HGNC:20471 LSM8

KEGG Gene (Homo sapiens):51691 LSM8

Monarch:51691 LSM8

NCBI Gene:51691 LSM8

OMIM:607288 LSM8

UCSC:O95777 LSM8

Reference Transcript

RefSeq:NM_016200.4 LSM8

Other Identifiers

11727896_a_at

11727897_a_at

17050736

219119_PM_at

219119_at

228529_PM_at

228529_at

230020_PM_at

230020_at

235470_PM_at

235470_at

3020813

3020814

3020818

3020822

3020824

3020825

3020826

3020827

3020828

3020829

3020830

3020831

3020832

3020833

3020834

3020835

3020836

3020837

3020838

3020839

3020840

3020842

3020844

50847_at

51691

56028_at

60979_at

61189_at

74600_g_at

76127_at

8135688

91567_at

A_24_P63969

GE500071

GE80187

GE868862

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005688

GO:0006397

GO:0008380

GO:0016071

GO:0017070

GO:0043226

GO:0046540

GO:0071005

GO:0071011

GO:0120115

GO:1990904

HMNXSV003009798

Hs.115916.0.A1_3p_at

Hs.122460.0.A1_3p_at

Hs.285724.0.A1_3p_at

ILMN_1805590

PH_hs_0026075

TC07000728.hg

g7706424_3p_at

Participates

as a component of

LSM2-8 complex [nucleoplasm] (Homo sapiens)

Inferred To

l(3)neo7 [nucleoplasm] (Drosophila melanogaster)

lsm-8 [nucleoplasm] (Caenorhabditis elegans)

LSM8 [nucleoplasm] (Bos taurus)

LSM8 [nucleoplasm] (Canis familiaris)

LSM8 [nucleoplasm] (Danio rerio)

LSM8 [nucleoplasm] (Gallus gallus)

LSM8 [nucleoplasm] (Plasmodium falciparum)

LSM8 [nucleoplasm] (Sus scrofa)

znf608 [nucleoplasm] (Xenopus tropicalis)

Lsm8 [nucleoplasm] (Mus musculus)

Lsm8 [nucleoplasm] (Rattus norvegicus)

lsm8 [nucleoplasm] (Dictyostelium discoideum)

lsm8 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_057284.1

OpenTargets

ENSG00000128534

GeneCards

O95777

HPA

ENSG00000128534-LSM8

Ensembl

ENSP00000249299, ENST00000249299, ENSG00000128534

PRO

O95777

Pharos - Targets

O95777

PDB

6AHD, 7ABG, 6QX9, 6QW6, 6AH0, 5O9Z, 3JCR

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15