Reactome | FTL [extracellular region]

FTL [extracellular region]

Stable Identifier

R-HSA-2187214

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Ferritin light chain, FRIL_HUMAN

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Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class A Receptors (Homo sapiens)
    - SCARA5 binds ligands (Homo sapiens)
      - Ligands of SCARA5 [extracellular region] (Homo sapiens)
        
        Ferritin [extracellular region] (Homo sapiens)
        
        Ferritin Complex Chains [extracellular region] (Homo sapiens)
        
        FTL [extracellular region] (Homo sapiens)
      - SCARA5:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of SCARA5 [extracellular region] (Homo sapiens)
        
        Ferritin [extracellular region] (Homo sapiens)
        
        Ferritin Complex Chains [extracellular region] (Homo sapiens)
        
        FTL [extracellular region] (Homo sapiens)
    - SCARA5:ligand is endocytosed (Homo sapiens)
      - SCARA5:Ligand [plasma membrane] (Homo sapiens)
        
        Ligands of SCARA5 [extracellular region] (Homo sapiens)
        
        Ferritin [extracellular region] (Homo sapiens)
        
        Ferritin Complex Chains [extracellular region] (Homo sapiens)
        
        FTL [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02792 FTL

Gene Names

FTL

Chain

initiator methionine:, chain:2-175

Reference Genes

BioGPS Gene:2512 FTL

COSMIC (genes):FTL FTL

CTD Gene:2512 FTL

dbSNP Gene:2512 FTL

ENSEMBL:ENSG00000087086 FTL

HGNC:3999 FTL

KEGG:hsa:2512 FTL

Monarch:2512 FTL

NCBI Gene:2512 FTL

OMIM:134790 FTL

UCSC:P02792 FTL

Reference Transcript

RefSeq:NM_000146.3 FTL

Other Identifiers

11755280_x_at

11757269_s_at

11757326_s_at

11757327_x_at

11757346_s_at

11757728_s_at

11757787_x_at

11758182_x_at

16863939

212788_PM_x_at

212788_x_at

213187_PM_x_at

213187_x_at

2512

35083_at

3838095

3838096

3838097

3838099

3838102

3838103

3838104

3838105

3838106

3838107

3838108

3838110

3874609

3874610

3874611

3972940

43423_s_at

8030171

A_14_P128048

A_23_P50498

A_23_P50504

GO:0005506

GO:0005515

GO:0005576

GO:0005737

GO:0005764

GO:0005773

GO:0005776

GO:0005829

GO:0006826

GO:0006879

GO:0006880

GO:0008198

GO:0008199

GO:0016020

GO:0031410

GO:0035578

GO:0042802

GO:0043226

GO:0044754

GO:0046872

GO:0070062

GO:0070288

HMNXSV003057940

Hs.111334.1.S1_3p_a_at

Hs.324746.2.S1_3p_s_at

ILMN_1740429

ILMN_1814823

M11147_at

TC19000717.hg

TC19002195.hg

TC20000047.hg

g7662555_3p_x_at

Participates

as a member of

Other forms of this molecule

FTL [endocytic vesicle lumen]

FTL [azurophil granule lumen]

FTL [cytosol]

Inferred To

Fer2LCH [extracellular region] (Drosophila melanogaster)

fthl31 [extracellular region] (Danio rerio)

fthl27 [extracellular region] (Danio rerio)

fthl28 [extracellular region] (Danio rerio)

Homologues of FTL [extracellular region] (Caenorhabditis elegans)

Homologues of FTL [extracellular region] (Danio rerio)

Homologues of FTL [extracellular region] (Drosophila melanogaster)

Homologues of FTL [extracellular region] (Rattus norvegicus)

FTL [extracellular region] (Bos taurus)

FTL [extracellular region] (Caenorhabditis elegans)

FTL [extracellular region] (Canis familiaris)

FTL [extracellular region] (Mus musculus)

FTL [extracellular region] (Rattus norvegicus)

FTL [extracellular region] (Sus scrofa)

Fer1HCH [extracellular region] (Drosophila melanogaster)

Fer3HCH [extracellular region] (Drosophila melanogaster)

MGC75752 [extracellular region] (Xenopus tropicalis)

Ftl1l2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000137.2

ENSEMBL

ENSP00000366525

OpenTargets

ENSG00000087086

HPA

ENSG00000087086-FTL

PRO

P02792

Pharos - Targets

P02792

Orphanet

FTL

HMDB Protein

HMDBP02077

PDB

6WX6, 2FFX, 2FG8, 5LG8, 2FG4, 6TSF, 6TSA, 6TR9, 6TS1, 4V6B, 6TS0, 3KXU, 6TSJ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.782	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	20
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.508	3