Reactome | MT-CO3 [mitochondrial inner membrane]

MT-CO3 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - CO binds to Cytochrome c oxidase (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
      - Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO3 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00414 MT-CO3

Gene Names

MT-CO3, COIII, COXIII, MTCO3

Chain

chain:1-261

Reference Genes

BioGPS Gene:4514 MT-CO3

COSMIC (genes):MT-CO3 MT-CO3

CTD Gene:4514 MT-CO3

dbSNP Gene:4514 MT-CO3

ENSEMBL:ENSG00000198938 MT-CO3

ENSEMBL_homo_sapiens_GENE:ENSG00000198938.2 MT-CO3

HGNC:7422 MT-CO3

KEGG Gene (Homo sapiens):4514 MT-CO3

Monarch:4514 MT-CO3

NCBI Gene:4514 MT-CO3

OMIM:516050 MT-CO3

Reference Transcript

RefSeq:NC_012920.1 MT-CO3

Other Identifiers

11762922_s_at

11762923_x_at

1553588_PM_at

1553588_at

17100665

17100667

17100669

17100671

17100673

17126270

2315319

4037642

4037643

4037644

4037645

4037646

4037647

4037648

4037649

4037651

4037653

4037655

4037657

4037658

4037659

4037660

4514

8165669

8165672

8165674

8165676

A_23_P360209

A_33_P3336696

GO:0003824

GO:0004129

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005751

GO:0006091

GO:0006123

GO:0008535

GO:0009055

GO:0016020

GO:0016491

GO:0019646

GO:0022904

GO:0031966

GO:0043226

GO:0045277

GO:0045333

GO:0055085

GO:0065003

GO:1902600

HMNXSV003008622

HMNXSV003015713

Hs2Affx.1.41.S1_3p_s_at

Hs2Affx.1.52.S1_3p_at

PH_hs_0033947

PH_hs_0036541

TC0M000006.hg

TC0M000007.hg

TC0M000022.hg

Participates

as a component of

MT-CO3:PE:CL [mitochondrial inner membrane] (Homo sapiens)

Inferred To

COX3 [mitochondrial inner membrane] (Bos taurus)

COX3 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

MT-CO3 [mitochondrial inner membrane] (Gallus gallus)

MT-CO3 [mitochondrial inner membrane] (Sus scrofa)

mt:CoIII [mitochondrial inner membrane] (Drosophila melanogaster)

mt-Co3 [mitochondrial inner membrane] (Mus musculus)

cox3 [mitochondrial inner membrane] (Dictyostelium discoideum)

cox3 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Mt-co3 [mitochondrial inner membrane] (Rattus norvegicus)

Ghost homologue of MT-CO3 [mitochondrial inner membrane] (Canis familiaris)

ctc-3 [mitochondrial inner membrane] (Caenorhabditis elegans)

mt-co3 [mitochondrial inner membrane] (Danio rerio)

mt-co3 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

YP_003024032.1

OpenTargets

ENSG00000198938

IntEnz

7.1.1.9

HPA

ENSG00000198938-MT-CO3

GeneCards

P00414

Ensembl

ENSP00000354982, ENST00000362079, ENSG00000198938

PRO

P00414

Pharos - Targets

P00414

Orphanet

16473

HMDB Protein

HMDBP07034

PDB

5Z62

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.508	3