Reactome | VAMP2 [plasma membrane]

VAMP2 [plasma membrane]

Stable Identifier

R-HSA-210516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Other interleukin signaling (Homo sapiens)
      - TXLNA (IL14) binds syntaxin1A (Homo sapiens)
        
        STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
        
        SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - PICALM binds R-SNAREs (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2,3,8 [plasma membrane] (Homo sapiens)
        
        VAMP2 [plasma membrane] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)
      - VAMP2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63027 VAMP2

Gene Names

VAMP2, SYB2

Chain

initiator methionine:, chain:2-116

Reference Genes

BioGPS Gene:6844 VAMP2

COSMIC (genes):VAMP2 VAMP2

CTD Gene:6844 VAMP2

dbSNP Gene:6844 VAMP2

ENSEMBL:ENSG00000220205 VAMP2

HGNC:12643 VAMP2

KEGG:hsa:6844 VAMP2

Monarch:6844 VAMP2

NCBI Gene:6844 VAMP2

OMIM:185881 VAMP2

UCSC:P63027 VAMP2

Reference Transcript

RefSeq:NM_014232.2 VAMP2

Other Identifiers

11716067_at

11716068_a_at

16840876

201556_PM_s_at

201556_s_at

201557_PM_at

201557_at

214792_PM_x_at

214792_x_at

32254_at

3744218

3744219

3744220

3744221

3744222

3744223

3744224

3744225

3744226

3744227

3744228

6844

8012376

A_23_P164341

A_24_P313576

A_33_P3213493

A_33_P3409886

GE62982

GO:0000149

GO:0002376

GO:0005484

GO:0005515

GO:0005516

GO:0005543

GO:0005802

GO:0005829

GO:0005886

GO:0006887

GO:0006906

GO:0008021

GO:0008076

GO:0008289

GO:0009749

GO:0015031

GO:0016020

GO:0016079

GO:0016192

GO:0017075

GO:0017156

GO:0017157

GO:0019905

GO:0030136

GO:0030141

GO:0030667

GO:0030669

GO:0030672

GO:0031201

GO:0031410

GO:0031982

GO:0032869

GO:0035493

GO:0042589

GO:0043001

GO:0043005

GO:0043226

GO:0043231

GO:0043308

GO:0044306

GO:0045202

GO:0048306

GO:0048471

GO:0048488

GO:0060090

GO:0060203

GO:0060291

GO:0060627

GO:0061024

GO:0061025

GO:0061202

GO:0065003

GO:0070032

GO:0070033

GO:0070044

GO:0070083

GO:0072659

GO:0090316

GO:1902259

HMNXSV003039309

Hs.194534.1.A1_3p_a_at

Hs.194534.1.A1_3p_x_at

ILMN_1713491

ILMN_1911044

M36205_at

PH_hs_0002231

TC17002850.hg

g12803794_3p_a_at

g12803794_3p_x_at

g7657674_3p_at

g7657674_3p_x_at

Participates

as a member of

VAMP2,3,8 [plasma membrane] (Homo sapiens)

as an output of

Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)

as a candidate of

SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)

as a component of

SNARE complex [plasma membrane] (Homo sapiens)

Other forms of this molecule

VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]

VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]

VAMP2 [synaptic vesicle membrane]

VAMP2(59-116) [synaptic vesicle membrane]

VAMP2(2-58) [cytosol]

VAMP2(2-76) [cytosol]

VAMP2(77-116) [synaptic vesicle membrane]

VAMP2(60-116) [synaptic vesicle membrane]

VAMP2(2-59) [cytosol]

VAMP2(82-116) [synaptic vesicle membrane]

VAMP2(2-81) [cytosol]

VAMP2 [secretory granule membrane]

VAMP2 [cytosol]

VAMP2 [endoplasmic reticulum membrane]

VAMP2 [cytoplasmic vesicle membrane]

VAMP2 [lysosomal membrane]

VAMP2 [Golgi membrane]

VAMP2 [clathrin-coated endocytic vesicle membrane]

Inferred To

sybB [plasma membrane] (Dictyostelium discoideum)

VAMP2 [plasma membrane] (Bos taurus)

VAMP2 [plasma membrane] (Canis familiaris)

VAMP2 [plasma membrane] (Drosophila melanogaster)

VAMP2 [plasma membrane] (Sus scrofa)

vamp-7 [plasma membrane] (Caenorhabditis elegans)

snb-5 [plasma membrane] (Caenorhabditis elegans)

snb-2 [plasma membrane] (Caenorhabditis elegans)

vamp2 [plasma membrane] (Danio rerio)

vamp2 [plasma membrane] (Xenopus tropicalis)

sybA [plasma membrane] (Dictyostelium discoideum)

snb-6 [plasma membrane] (Caenorhabditis elegans)

Homologues of VAMP2 [plasma membrane] (Caenorhabditis elegans)

Homologues of VAMP2 [plasma membrane] (Dictyostelium discoideum)

Homologues of VAMP2 [plasma membrane] (Drosophila melanogaster)

snb-7 [plasma membrane] (Caenorhabditis elegans)

Vamp2 [plasma membrane] (Mus musculus)

Vamp2 [plasma membrane] (Rattus norvegicus)

snb-1 [plasma membrane] (Caenorhabditis elegans)

Syb [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_055047.2

OpenTargets

ENSG00000220205

ENSEMBL

ENSP00000314214, ENST00000316509

HPA

ENSG00000220205-VAMP2

PRO

P63027

Pharos - Targets

P63027

PDB

3RL0, 7UDC, 3FII, 3FIE, 3RK3, 3RK2

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60880-2 SNAP25			0.764	9
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.718	6
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.666	5
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.666	4
UniProt:P61266 STX1B	3	STX1B(1-?) [cytosol] (R-HSA-5246520) STX1B(?-288) [plasma membrane] (R-HSA-5246519) STX1B [plasma membrane] (R-HSA-181479)	0.659	4
UniProt:O14810 CPLX1	1	CPLX1 [cytosol] (R-HSA-210385)	0.656	3
UniProt:Q8IWB7 WDFY1			0.643	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.632	5
UniProt:O94806 PRKD3	1	PRKD3 [cytosol] (R-HSA-58212)	0.618	7
UniProt:O55012	3	Picalm [Golgi membrane] (R-RNO-434341) Picalm [cytoplasmic vesicle membrane] (R-RNO-429812) Picalm [cytosol] (R-RNO-8867593)	0.558	2
UniProt:Q57236 Q57236			0.558	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q5T0T0 MARH8			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q8TBB6 S7A14			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q3ZAQ7 VMA21			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:P31937 HIBADH	1	HIBADH [mitochondrial matrix] (R-HSA-70882)	0.556	3
UniProt:Q96IK0 TM101			0.556	3
UniProt:Q9HA82 CERS4	1	CERS4 [endoplasmic reticulum membrane] (R-HSA-428138)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O75558 STX11			0.527	2
UniProt:Q8N4C7 STX19			0.527	2
UniProt:Q86Y82 STX12			0.527	4
UniProt:Q16563 SYPL1			0.527	2
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.527	2

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