Reactome | COPS3 [cytosol]

COPS3 [cytosol]

Stable Identifier

R-HSA-416973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 3, CSN3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UNS2 COPS3

Gene Names

COPS3, CSN3

Chain

initiator methionine:, chain:2-423

Reference Genes

BioGPS Gene:8533 COPS3

COSMIC (genes):COPS3 COPS3

CTD Gene:8533 COPS3

dbSNP Gene:8533 COPS3

ENSEMBL:ENSG00000141030 COPS3

ENSEMBL_homo_sapiens_GENE:ENSG00000141030.13 COPS3

HGNC:2239 COPS3

KEGG Gene (Homo sapiens):8533 COPS3

Monarch:8533 COPS3

NCBI Gene:8533 COPS3

OMIM:604665 COPS3

UCSC:Q9UNS2 COPS3

Reference Transcript

Other Identifiers

11757601_a_at

16841885

202078_PM_at

202078_at

35349_at

3747718

3747719

3747720

3747721

3747725

3747727

3747728

3747730

3747734

3747735

3747736

3747740

3747742

3747743

3747744

3747745

3747746

8013094

8533

A_23_P89199

GE54246

GO:0000338

GO:0001701

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0007165

GO:0008180

GO:0009416

GO:0023052

GO:0030163

GO:0032991

GO:0036211

GO:0043226

GO:0045116

GO:0048471

GO:0048856

GO:1902162

GO:2000434

HMNXSV003018891

HMNXSV003031923

ILMN_1770732

PH_hs_0000611

TC17001186.hg

g4502974_3p_at

Participates

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

COPS3 [nucleoplasm]

Inferred To

csn-3 [cytosol] (Caenorhabditis elegans)

COPS3 [cytosol] (Bos taurus)

COPS3 [cytosol] (Canis familiaris)

COPS3 [cytosol] (Gallus gallus)

COPS3 [cytosol] (Sus scrofa)

CSN3 [cytosol] (Drosophila melanogaster)

cops3 [cytosol] (Danio rerio)

cops3 [cytosol] (Xenopus tropicalis)

Cops3 [cytosol] (Mus musculus)

Cops3 [cytosol] (Rattus norvegicus)

csn3 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001303286.1, NP_001303287.1, NP_003644.2, NP_001303285.1, NP_001186054.1, NP_001303283.1, NP_001303284.1, XP_005256894.1

OpenTargets

ENSG00000141030

GeneCards

Q9UNS2

HPA

ENSG00000141030-COPS3

Ensembl

ENSG00000141030, ENSP00000268717, ENST00000539941, ENST00000268717, ENSP00000437606

PRO

Q9UNS2

Pharos - Targets

Q9UNS2

PDB

8H3A, 4D10, 6R7N, 8H3F, 6R6H, 8H38, 4WSN, 6R7H, 4D18, 6R7I, 6R7F

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.725	4
UniProt:O14832 PHYH	4	PHYH [peroxisomal matrix] (R-HSA-389574) PHYH(1-338) [cytosol] (R-HSA-9033143) PHYH(1-338) [peroxisomal matrix] (R-HSA-9033535) PHYH(1-30) [peroxisomal matrix] (R-HSA-9033518)	0.675	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	22
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.581	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q8TBF2 PRXL2B	1	FAM213B [cytosol] (R-HSA-2142703)	0.556	5
UniProt:P02545-2 LMNA	5	LMNA-2 [nuclear envelope] (R-HSA-912378) p-S22, S395-LMNA-2 [nucleoplasm] (R-HSA-5229019) p-S395-LMNA-2 [nucleoplasm] (R-HSA-5228740) Lamin C [nucleoplasm] (R-HSA-264872) LMNA-2 [cytosol] (R-HSA-2995387)	0.556	3
UniProt:Q16143 SNCB	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
UniProt:P51149 RAB7A	7	RAB7A [secretory granule membrane] (R-HSA-6804969) RAB7A [plasma membrane] (R-HSA-6804990) RAB7A [cytosol] (R-HSA-8870415) RAB7A [phagocytic vesicle membrane] (R-HSA-9636586) RAB7A [lysosomal membrane] (R-HSA-2213231) GGC-RAB7A [cytosol] (R-HSA-8870438) GGC-RAB7A [lysosomal membrane] (R-HSA-8877454)	0.556	3
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) NOS3 [cytosol] (R-HSA-202114)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	2
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.527	3
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.527	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.508	2
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.462	6

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