Reactome | Ub-63-UBA52(1-76) [cytosol]

Ub-63-UBA52(1-76) [cytosol]

Stable Identifier

R-HSA-939169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ub-63-UBA52, K63 ubiquitin (UBA52)

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
        
        Activated TAK complexes [cytosol] (Homo sapiens)
        
        K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Homo sapiens)
        
        K63polyUb [cytosol] (Homo sapiens)
        
        K63-Ub [cytosol] (Homo sapiens)
        
        Ub-63-UBA52(1-76) [cytosol] (Homo sapiens)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
        
        K63polyUb [cytosol] (Homo sapiens)
        
        K63-Ub [cytosol] (Homo sapiens)
        
        Ub-63-UBA52(1-76) [cytosol] (Homo sapiens)
        
        DDX58 is K63 polyubiquitinated (Homo sapiens)
        
        K63polyUb [cytosol] (Homo sapiens)
        
        K63-Ub [cytosol] (Homo sapiens)
        
        Ub-63-UBA52(1-76) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62987 UBA52

Gene Names

UBA52, UBCEP2

Chain

chain:1-76, chain:77-128

Reference Genes

BioGPS Gene:7311 UBA52

COSMIC (genes):UBA52 UBA52

CTD Gene:7311 UBA52

dbSNP Gene:7311 UBA52

ENSEMBL:ENSG00000221983 UBA52

HGNC:12458 UBA52

KEGG:hsa:7311 UBA52

Monarch:7311 UBA52

NCBI Gene:7311 UBA52

OMIM:191321 UBA52

UCSC:P62987 UBA52

Reference Transcript

Other Identifiers

11729104_x_at

11756215_x_at

16859825

221700_PM_s_at

221700_s_at

3476750

3537801

3825202

3825203

3825204

3825205

3825206

3825207

3825208

3825209

3825210

3825211

3825212

3825213

3825214

3825215

3825216

3825217

3825218

3825219

3825220

3825221

3825222

3825224

58604_s_at

7311

8027024

A_14_P119934

A_23_P56188

A_23_P56195

A_24_P173325

A_24_P65779

GE79164

GE85590

GE85604

GO:0002181

GO:0003735

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005741

GO:0005765

GO:0005783

GO:0005789

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0010008

GO:0016567

GO:0019941

GO:0022625

GO:0022626

GO:0022627

GO:0030666

GO:0031386

GO:0031625

GO:0031982

GO:0036211

GO:0043226

GO:0043229

GO:0045202

GO:0070062

GO:1990904

HMNXSV003054363

ILMN_1782977

ILMN_2368576

PH_hs_0028727

PH_hs_0037046

TC19000360.hg

X56997_rna1_at

g13569611_3p_s_at

Participates

as a member of

K63-Ub [cytosol] (Homo sapiens)

Other forms of this molecule

UBA52(1-76) [endocytic vesicle membrane]

Ub-33-UBA52(1-76) [mitochondrial outer membrane]

Ub-63-UBA52(1-76) [mitochondrial outer membrane]

Ub-6-UBA52(1-76) [mitochondrial outer membrane]

Ub-11-UBA52(1-76) [mitochondrial outer membrane]

Ub-48-UBA52(1-76) [mitochondrial outer membrane]

Ub-29-UBA52(1-76) [mitochondrial outer membrane]

UBA52(1-76) [lysosomal lumen]

UBA52(1-76) [cytosol]

p-S65-UBA52(1-76) [mitochondrial outer membrane]

Ub-48-UBA52(1-76) [cytosol]

UBA52(1-76) [mitochondrial outer membrane]

UBA52(1-76) [late endosome lumen]

Ub-6-UBA52(1-76) [nucleoplasm]

Ub-63-UBA52(1-76) [nucleoplasm]

Ub-48-UBA52(1-76) [nucleoplasm]

UBA52(1-76) [nucleoplasm]

Ub-11-UBA52(1-76) [cytosol]

Ub-63-UBA52(1-76) [plasma membrane]

Ub-63-UBA52(1-76) [endosome membrane]

Ub-11-UBA52(1-76) [nucleoplasm]

Ub-33-UBA52(1-76) [nucleoplasm]

Ub-29-UBA52(1-76) [nucleoplasm]

Ub-27-UBA52(1-76) [nucleoplasm]

UBA52(1-76) [endoplasmic reticulum membrane]

M1-UBA52(1-76) [cytosol]

Ub-33-UBA52(1-76) [cytosol]

Ub-27-UBA52(1-76) [cytosol]

Ub-6-UBA52(1-76) [cytosol]

Ub-29-UBA52(1-76) [cytosol]

RPL40 [cytosol]

UBA52(1-76) [plasma membrane]

UBA52(1-76) [endosome membrane]

Ub-48-UBA52(1-76) [endocytic vesicle membrane]

Ub-48-UBA52(1-76) [lysosomal membrane]

Ub-48-UBA52(1-76) [endoplasmic reticulum membrane]

adenylatedG76-UBA52(1-76) [cytosol]

UBA52(1-128) [cytosol]

adenylatedG76-UBA52(1-76) [nucleoplasm]

N6-glycyl-L-lysine-UBA52(1-76) [cytosol]

Ub-27-UBA52(1-76) [mitochondrial outer membrane]

Inferred To

UBA52 [cytosol] (Bos taurus)

UBA52 [cytosol] (Canis familiaris)

UBA52 [cytosol] (Sus scrofa)

ubi4 [cytosol] (Schizosaccharomyces pombe)

UBI4 [cytosol] (Saccharomyces cerevisiae)

ubqB [cytosol] (Dictyostelium discoideum)

uba52 [cytosol] (Danio rerio)

uba52 [cytosol] (Xenopus tropicalis)

Ubi-p5E [cytosol] (Drosophila melanogaster)

K63-ubiquitin (UBB 1) [cytosol] (Gallus gallus)

Ubbl1 [cytosol] (Rattus norvegicus)

Ub-63-RPS27A(1-76) [cytosol] (Plasmodium falciparum)

ubl-1 [cytosol] (Caenorhabditis elegans)

Uba52 [cytosol] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine at 63

Coordinate

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001029102.1, NP_001307948.1, NP_001307949.1, NP_001307946.1, NP_001307947.1, NP_003324.1

OpenTargets

ENSG00000221983

ENSEMBL

ENST00000599551, ENST00000599595, ENSP00000470419, ENST00000442744, ENSP00000470507, ENST00000596304, ENST00000597451, ENST00000595158, ENSP00000471622, ENSP00000472545, ENST00000596273, ENST00000598780, ENSP00000396910, ENSP00000471062, ENSP00000472264, ENSP00000388107, ENST00000430157, ENST00000595683, ENSP00000473048, ENSP00000471464

HPA

ENSG00000221983-UBA52

PRO

P62987

Pharos - Targets

P62987

GlyGen

P62987

PDB

5JBY, 8IPJ, 4HJK, 8OHD, 5HPT, 6ZME, 7OWC, 5GO7, 6ZM7, 2MJB, 5JBV, 5HPS, 6Y6X, 6Z6L, 5GOJ, 4PIH, 5GOI, 6ZMO, 5GOD, 2NBE, 4PIJ, 7BHP, 8QFD, 7XNY, 7ZH4, 8JDK, 5GOH, 6OLE, 2N3V, 2N3U, 5GOG, 6OLF, 7XNX, 6OLZ, 4PIG, 4V6X, 7UN3, 8OJ5, 8JDM, 4UG0, 2MUR, 7WFC, 7ZF1, 6XA1, 6IP5, 5AJ0, 2LJ5, 6Y2L, 4RF0, 6Y57, 6QZP, 5HPK, 2RSU, 8OJ0, 5HPL, 6IP8, 7M3Q, 5T2C, 4RF1, 7F5S, 8IFD, 6OLI, 4XKL, 6Y0G, 6OM0, 6Z6M, 5GOB, 8OJ8, 5J8P, 5GOK, 6Z6N, 2NBD, 5GOC, 7ZH3, 8QOI, 7XD0, 4JIO, 8JDL, 6OM7, 6ZMI, 5LKS, 4S1Z, 8IFE, 8Y0W, 6OLG, 8JDJ, 4P4H, 5J26, 8Y0X, 6LQM, 7AY1, 5GO8, 6IP6, 2N3W, 2MBH

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C5 RNF11			0.666	4
UniProt:Q15038 DAZP2			0.666	7
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.659	3
UniProt:Q6ICB0 DESI1			0.601	4
UniProt:Q99732 LITAF			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q96B67 ARRD3			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:Q9UJ41-4 RABGEF1			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q92567-2 FAM168A			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q02742 GCNT1	1	GCNT1 [Golgi membrane] (R-HSA-914020)	0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:O43173 ST8SIA3	1	ST8SIA3 [Golgi membrane] (R-HSA-1022124)	0.527	2
UniProt:Q86UY6 NAA40			0.527	2
UniProt:Q9UBP4 DKK3			0.527	2
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.527	2
UniProt:A4D1S0 KLRG2			0.527	2
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2

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