Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EXOC5 [cytosol]
Stable Identifier
R-HSA-5623383
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SEC10, SEC10L1
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00471 EXOC5
Gene Names
EXOC5, SEC10, SEC10L1
Chain
initiator methionine:, chain:2-708
Reference Genes
BioGPS Gene:10640 EXOC5
COSMIC (genes):EXOC5 EXOC5
CTD Gene:10640 EXOC5
dbSNP Gene:10640 EXOC5
ENSEMBL:ENSG00000070367 EXOC5
HGNC:10696 EXOC5
Monarch:10640 EXOC5
NCBI Gene:10640 EXOC5
OMIM:604469 EXOC5
UCSC:O00471 EXOC5
Reference Transcript
RefSeq:NM_006544.3 EXOC5
Other Identifiers
10640
11719456_at
11719457_s_at
11719458_at
11719459_at
11749681_a_at
11749682_s_at
11757786_s_at
16793353
218748_PM_s_at
218748_s_at
222726_3p_s_at
222726_PM_s_at
222726_s_at
225084_PM_at
225084_at
228418_PM_at
228418_at
2729215
2729216
2729217
2729222
3566301
3566303
3566305
3566306
3566307
3566308
3566310
3566311
3566312
3566315
3566316
3566318
3566320
3566321
3566322
3566323
3566324
3566325
3566326
3566327
3566328
3566329
3566331
3566333
3566334
3566337
3566338
3566339
3566340
3566341
3566342
3566343
3566344
3566345
3566351
3566352
45744_at
57159_at
7979367
8095333
88639_at
A_23_P14464
A_24_P224219
A_24_P256830
A_32_P172755
GE78968
GO:0000145
GO:0000281
GO:0000910
GO:0001736
GO:0005515
GO:0005737
GO:0005829
GO:0006887
GO:0006892
GO:0006893
GO:0006904
GO:0012501
GO:0015031
GO:0016192
GO:0030496
GO:0031267
GO:0044782
GO:0061024
GO:0072659
GO:0090148
GO:0090522
GO:1904019
GO:1905515
HMNXSV003048444
Hs.279947.0.S2_3p_s_at
Hs.29494.1.S1_3p_at
Hs.29494.2.S1_3p_at
Hs.29494.2.S1_3p_x_at
ILMN_1788625
PH_hs_0029885
TC14001170.hg
U85946_at
g5730036_3p_a_at
Participates
as a component of
exocyst complex [cytosol] (Homo sapiens)
Other forms of this molecule
EXOC5 [cytosol]
Inferred To
EXOC5 [cytosol]
(Bos taurus)
EXOC5 [cytosol]
(Canis familiaris)
EXOC5 [cytosol]
(Gallus gallus)
EXOC5 [cytosol]
(Sus scrofa)
Sec10 [cytosol]
(Drosophila melanogaster)
Exoc5 [cytosol]
(Mus musculus)
Exoc5 [cytosol]
(Rattus norvegicus)
sec-10 [cytosol]
(Caenorhabditis elegans)
exoc5 [cytosol]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000070367
ENSEMBL
ENSP00000484855
,
ENST00000621441
HPA
ENSG00000070367-EXOC5
PRO
O00471
Pharos - Targets
O00471
GlyGen
O00471
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.841
9
UniProt:Q9Y2D4 EXC6B
0.793
8
UniProt:O60645 EXOC3
2
EXOC3 [secretory granule membrane]
(R-HSA-2872286)
EXOC3 [cytosol]
(R-HSA-5623379)
0.725
5
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.725
6
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.718
6
UniProt:P00973-2 OAS1
0.718
6
UniProt:Q05D60 DEUP1
0.718
11
UniProt:P61106 RAB14
7
GGC-RAB14 [cytoplasmic vesicle membrane]
(R-HSA-1445086)
GGC-RAB14 [recycling endosome membrane]
(R-HSA-8876593)
GGC-RAB14 [cytosol]
(R-HSA-8873763)
RAB14 [cytosol]
(R-HSA-8873701)
RAB14 [early endosome membrane]
(R-HSA-8871372)
RAB14 [plasma membrane]
(R-HSA-6806438)
RAB14 [tertiary granule membrane]
(R-HSA-6800407)
0.718
6
UniProt:P43360 MAGA6
0.718
6
UniProt:P20338 RAB4A
5
GGC-RAB4A [cytoplasmic vesicle membrane]
(R-HSA-1458526)
GGC-RAB4A [cytosol]
(R-HSA-8874045)
RAB4A [cytosol]
(R-HSA-8873709)
RAB4A [early endosome membrane]
(R-HSA-8871356)
GGC-RAB4A [recycling endosome membrane]
(R-HSA-8875666)
0.718
6
UniProt:P61018 RAB4B
5
GGC-RAB4B [cytosol]
(R-HSA-8874049)
RAB4B [cytosol]
(R-HSA-8873680)
GGC-RAB4B [recycling endosome membrane]
(R-HSA-8875675)
RAB4B [plasma membrane]
(R-HSA-6804989)
RAB4B [secretory granule membrane]
(R-HSA-6804976)
0.718
6
UniProt:O14787 TNPO2
0.666
4
UniProt:Q9BQD3 KXDL1
0.666
4
UniProt:Q8N3L3 TXLNB
0.666
4
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.638
4
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:P02511 CRYAB
1
CRYAB [nucleoplasm]
(R-HSA-6806336)
0.556
3
UniProt:Q6PF05-3 TTC23L
0.556
3
UniProt:P00973 OAS1
1
OAS1 [cytosol]
(R-HSA-947486)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q99728 BARD1
13
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-9707286)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
BARD1 [nucleoplasm]
(R-HSA-5659775)
K6PolyUb-BARD1 [nucleoplasm]
(R-HSA-9701024)
BARD1 C83G [nucleoplasm]
(R-HSA-9699139)
BARD1 C50G [nucleoplasm]
(R-HSA-9699137)
BARD1 L44R [nucleoplasm]
(R-HSA-9699126)
BARD1 H68Y [nucleoplasm]
(R-HSA-9699151)
BARD1 W34R [nucleoplasm]
(R-HSA-9699166)
BARD1 G623W [nucleoplasm]
(R-HSA-9699148)
BARD1 C53W [nucleoplasm]
(R-HSA-9700807)
BARD1 C71Y [nucleoplasm]
(R-HSA-9700808)
BARD1 G623E [nucleoplasm]
(R-HSA-9699135)
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q9NWB7 IFT57
2
IFT57 [cilium]
(R-HSA-5610389)
IFT57 [ciliary tip]
(R-HSA-5625363)
0.556
3
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.556
5
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P02671-2 FGA
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.556
3
UniProt:P23560-2 BDNF
0.556
3
UniProt:P83876 TXNL4A
1
TXNL4A [nucleoplasm]
(R-HSA-71875)
0.556
3
UniProt:Q96E40 SACA9
0.556
3
UniProt:Q8N4P3 MESH1
0.556
3
UniProt:A0A0S2Z528 A0A0S2Z528
0.556
3
UniProt:Q5PSV4 BRM1L
0.556
3
UniProt:Q6FHV6 Q6FHV6
0.556
3
UniProt:Q13148 TADBP
0.556
6
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q96NE9 FRMD6
0.556
3
UniProt:P43357 MAGA3
0.556
3
UniProt:P53674 CRBB1
0.556
3
UniProt:Q96FV9 THOC1
1
THOC1 [nucleoplasm]
(R-HSA-8849130)
0.556
3
UniProt:Q68D86 C102B
0.556
3
IntAct:EBI-16430217 CCSB ISOFORM ID
0.556
3
UniProt:A0AVN2 A0AVN2
0.556
3
UniProt:A0A0S2Z4Q4 A0A0S2Z4Q4
0.556
3
UniProt:Q3B7T1-5 EDRF1
0.556
3
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.527
4
UniProt:Q9ULX7 CA14
1
CA14 [plasma membrane]
(R-HSA-1237018)
0.527
2
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
2
UniProt:Q9Y2V7 COG6
2
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
COG6 [Golgi membrane]
(R-HSA-2980958)
0.527
2
UniProt:Q9H410 DSN1
3
DSN1 [cytosol]
(R-HSA-375308)
DSN1 [azurophil granule lumen]
(R-HSA-6799218)
DSN1 [extracellular region]
(R-HSA-6806228)
0.527
3
UniProt:O75558 STX11
0.527
2
UniProt:O60939 SCN2B
1
SCN2B [plasma membrane]
(R-HSA-197905)
0.527
2
UniProt:P49146 NPY2R
1
NPY2R [plasma membrane]
(R-HSA-388905)
0.527
2
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.508
2
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.508
3
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.508
2
UniProt:P61006 RAB8A
6
RAB8A [Golgi membrane]
(R-HSA-2562535)
RAB8A [cytosol]
(R-HSA-5623399)
GGC-RAB8A [cytosol]
(R-HSA-8874063)
GGC-RAB8A [trans-Golgi network membrane]
(R-HSA-8876082)
RAB8A [recycling endosome membrane]
(R-HSA-8854145)
GGC-RAB8A [cytoplasmic vesicle membrane]
(R-HSA-1445093)
0.508
2
UniProt:O15014 ZN609
0.508
2
UniProt:Q13586 STIM1
1
STIM1 [endoplasmic reticulum membrane]
(R-HSA-434675)
0.508
2
UniProt:Q96KP1 EXOC2
2
EXOC2 [cytosol]
(R-HSA-5623376)
EXOC2 [plasma membrane]
(R-HSA-264887)
0.508
2
UniProt:Q9UPT5 EXOC7
2
EXOC7 [cytosol]
(R-HSA-5623386)
EXOC7 [plasma membrane]
(R-HSA-2872288)
0.508
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
