Reactome | Me2-R108,R112-SNRPB [nucleoplasm]

Me2-R108,R112-SNRPB [nucleoplasm]

Stable Identifier

R-HSA-192213

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

dimethylated Sm Protein B, Small nuclear ribonucleoprotein associated proteins B and B', snRNP-B, Sm protein B/B', Sm-B/Sm-B', SmB/SmB'

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- ATP-dependent chromatin remodelers (Homo sapiens)
  - CHD chromatin remodelers (Homo sapiens)
    - CHD1 and CHD2 subfamily (Homo sapiens)
      - CHD1:H3K4me3 interacts with post-initiation transcription complexes (Homo sapiens)
        
        CHD1:H3K4 nucleosome:FACT complex:U2 snRNP complex:PAF1C complex [nucleoplasm] (Homo sapiens)
        
        U2 snRNP [nucleoplasm] (Homo sapiens)
        
        U2 Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)
        
        U2 snRNP [nucleoplasm] (Homo sapiens)
        
        U2 Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        U2 snRNP [nucleoplasm] (Homo sapiens)
        
        U2 Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)
        
        U5 snRNP [nucleoplasm] (Homo sapiens)
        
        snRNP Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        U2 snRNP [nucleoplasm] (Homo sapiens)
        
        U2 Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)
        
        U5 snRNP [nucleoplasm] (Homo sapiens)
        
        snRNP Sm core complex [nucleoplasm] (Homo sapiens)
        
        Me2-R108,R112-SNRPB [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
11720283	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein Brahms, H, Meheus, L, de Brabandere, V, Fischer, U, Luhrmann, R	RNA	2001

External Reference Information

External Reference

UniProt:P14678 SNRPB

Gene Names

SNRPB, COD, SNRPB1

Chain

chain:1-240

Reference Genes

BioGPS Gene:6628 SNRPB

COSMIC - genes:SNRPB SNRPB

CTD Gene:6628 SNRPB

dbSNP Gene:6628 SNRPB

ENSEMBL:ENSG00000125835 SNRPB

HGNC:11153 SNRPB

KEGG:hsa:6628 SNRPB

Monarch:6628 SNRPB

NCBI Gene:6628 SNRPB

OMIM:182282 SNRPB

UCSC:P14678 SNRPB

Reference Transcript

Participates

as a member of

Me2-R108,R112-SNRPB,SNRPN [nucleoplasm] (Homo sapiens)

as a component of

snRNP Sm core complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

2xMe-SNRPB [cytosol]

SNRPB [cytosol]

SNRPB [nucleoplasm]

Inferred To

Me2-R108,R112-SNRPB [nucleoplasm] (Plasmodium falciparum)

Me2-R108,R112-SNRPB [nucleoplasm] (Sus scrofa)

smb1 [nucleoplasm] (Schizosaccharomyces pombe)

SMB1 [nucleoplasm] (Saccharomyces cerevisiae)

SNRPB [nucleoplasm] (Bos taurus)

SNRPB [nucleoplasm] (Canis familiaris)

SNRPB [nucleoplasm] (Gallus gallus)

Snrpb [nucleoplasm] (Mus musculus)

Snrpb [nucleoplasm] (Rattus norvegicus)

snr-2 [nucleoplasm] (Caenorhabditis elegans)

SmB [nucleoplasm] (Drosophila melanogaster)

snrpb [nucleoplasm] (Danio rerio)

snrpb [nucleoplasm] (Dictyostelium discoideum)

snrpb [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

symmetric dimethyl-L-arginine at 108

Coordinate

108

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Name

symmetric dimethyl-L-arginine at 112

Coordinate

112

PsiMod Name

symmetric dimethyl-L-arginine

PsiMod Definition

A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.

Cross References

RefSeq

NP_003082.1, NP_937859.1

OpenTargets

ENSG00000125835

ENSEMBL

ENSG00000125835, ENSP00000412566, ENST00000381342, ENST00000438552, ENSP00000370746

GeneCards

SNRPB

HPA

ENSG00000125835-SNRPB

PRO

P14678

Pharos - Targets

P14678

Orphanet

SNRPB

PDB

5Z57, 8Q7W, 6QX9, 8I0P, 5MQF, 6V4X, 8R0B, 8H6L, 3JCR, 8H6J, 4WZJ, 6FF7, 5XJC, 8I0T, 3CW1, 8QZS, 7W59, 8Q7V, 6QDV, 7W5B, 7VPX, 8Q91, 8I0W, 1D3B, 4PJO, 8H6E, 8R0A, 8QO9, 8I0V, 9GBW, 8R08, 6ICZ, 9FMD, 7EVO, 6ID1, 8Q7Q, 5Z56, 8Q7X, 9GCL, 8Y6O, 5O9Z, 8I0R, 7ABG, 6AH0, 7ABI, 8H6K, 6Y53, 8RO2, 6QW6, 7QTT, 8I0S, 8CH6, 5YZG, 7A5P, 8RC0, 7W5A, 8R7N, 3PGW, 8I0U, 8HK1, 8R09, 9GC0, 6ID0, 8C6J, 8RM5, 6Y5Q, 8Y7E, 5Z58, 7DVQ

Interactors (86)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.882	11
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219)	0.88	8
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.846	7
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.845	6
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.832	9
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.793	5
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.793	7
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.793	7
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.793	7
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.784	7
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.768	7
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.744	5
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.744	4
UniProt:Q15020 SART3			0.744	5
UniProt:P62308 SNRPG	2	SNRPG [cytosol] (R-HSA-191827) SNRPG [nucleoplasm] (R-HSA-71909)	0.734	5
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.725	5
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.725	5
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.669	4
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	3
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.669	4
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.669	4
UniProt:P38432 COIL			0.669	3
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	4
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.643	3
UniProt:Q8WXD5 GEMIN6	2	GEMIN6 [nucleoplasm] (R-HSA-191799) GEMIN6 [cytosol] (R-HSA-191771)	0.643	3
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.643	4
UniProt:Q8IYT2 CMTR2			0.643	4
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.643	5
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.643	4
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.643	3
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.643	3
UniProt:Q13523 PRP4K	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.643	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.643	6
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.643	4
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.643	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.59	2
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.564	2
UniProt:P54253 ATX1			0.556	3
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.547	2
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.547	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:Q96LT9 RNPC3	1	RNPC3 [nucleoplasm] (R-HSA-6787844)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.527	2
UniProt:Q6V1X1 DPP8			0.527	3
UniProt:Q9NYF8 BCLF1			0.527	2
UniProt:O14893 GEMIN2	2	GEMIN2 [nucleoplasm] (R-HSA-191795) GEMIN2 [cytosol] (R-HSA-191835)	0.527	2
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	5
UniProt:Q9BWJ5 SF3B5	1	SF3B5 [nucleoplasm] (R-HSA-71979)	0.527	2
UniProt:O43172 PRPF4	1	PRPF4 [nucleoplasm] (R-HSA-71890)	0.527	3
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.527	2
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	3
UniProt:Q9Y4F1 FARP1	1	FARP1 [cytosol] (R-HSA-9679578)	0.527	3
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	3
UniProt:Q6IN85 P4R3A			0.527	2
UniProt:Q6IEG0 SNRNP48	1	SNRNP48 [nucleoplasm] (R-HSA-6787849)	0.527	2
UniProt:Q9BWU0 NADAP			0.527	3
UniProt:Q8N5A5 ZGPAT			0.527	2
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.527	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.527	3
UniProt:Q9H6E5 TUT1	1	TUT1 [nucleoplasm] (R-HSA-9970846)	0.527	3
UniProt:Q8N954 GPT11			0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	3
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.527	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	2
UniProt:P62312 LSM6	2	LSM6 [nucleoplasm] (R-HSA-6806794) LSM6 [cytosol] (R-HSA-429936)	0.527	2
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	2
UniProt:Q9Y5B6 PAXB1			0.527	2
UniProt:Q9NWZ8 GEMIN8	2	GEMIN8 [nucleoplasm] (R-HSA-8932892) GEMIN8 [cytosol] (R-HSA-8932878)	0.527	3
UniProt:Q96GM8 TOE1			0.527	3
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:Q56P03 EAPP			0.527	3
UniProt:Q9UK45 LSM7	2	LSM7 [cytosol] (R-HSA-2028610) LSM7 [nucleoplasm] (R-HSA-6806802)	0.527	2
UniProt:Q9Y312 AAR2			0.527	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	3
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	3
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941) DDX41 [nucleoplasm] (R-HSA-9769601)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	2

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