Reactome | AQR [nucleoplasm]

AQR [nucleoplasm]

Stable Identifier

R-HSA-6781960

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Intron-binding protein aquarius, IBP160, Intron-binding protein of 160 kDa, KIAA0560

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - ERCC5 and RPA bind TC-NER site (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - Assembly of the pre-incision complex in TC-NER (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
    - Recovery of RNA synthesis after TC-NER (Homo sapiens)
      - TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)
      - XAB2 complex [nucleoplasm] (Homo sapiens)
        
        AQR [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60306 AQR

Gene Names

AQR, KIAA0560

Chain

chain:1-1485

Reference Genes

BioGPS Gene:9716 AQR

COSMIC (genes):AQR AQR

CTD Gene:9716 AQR

dbSNP Gene:9716 AQR

ENSEMBL:ENSG00000021776 AQR

ENSEMBL_homo_sapiens_GENE:ENSG00000021776.11 AQR

HGNC:29513 AQR

KEGG Gene (Homo sapiens):9716 AQR

Monarch:9716 AQR

NCBI Gene:9716 AQR

OMIM:610548 AQR

UCSC:O60306 AQR

Reference Transcript

RefSeq:NM_014691.2 AQR

Other Identifiers

11742845_at

11759408_at

16807027

212583_PM_at

212583_at

212584_PM_at

212584_at

228694_PM_at

228694_at

3453746

3617752

3617754

3617756

3617758

3617759

3617760

3617762

3617764

3617769

3617772

3617775

3617777

3617778

3617779

3617780

3617781

3617784

3617785

3617786

3617787

3617788

3617789

3617791

3617792

3617793

3617794

3617795

3617796

3617797

3617799

3617800

3617801

3617804

3617806

3617807

3617809

3617810

3617812

3617813

3617814

3617816

3617819

3617820

3617821

41712_at

58366_at

7987325

9716

A_24_P280378

A_24_P316305

A_24_P749042

GE894794

GO:0000166

GO:0000398

GO:0003723

GO:0003724

GO:0003727

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0016020

GO:0016071

GO:0016787

GO:0016887

GO:0034458

GO:0043226

GO:0071007

GO:0071013

GO:0140098

GO:0140657

HMNXSV003034877

HMNXSV003052375

Hs.129952.0.S1_3p_at

Hs.129952.0.S2_3p_at

Hs.16886.0.A1_3p_at

ILMN_1717154

ILMN_2177460

PH_hs_0016401

PH_hs_0040773

TC15001202.hg

Participates

as a component of

Inferred To

AQR [nucleoplasm] (Bos taurus)

AQR [nucleoplasm] (Canis familiaris)

AQR [nucleoplasm] (Gallus gallus)

AQR [nucleoplasm] (Mus musculus)

AQR [nucleoplasm] (Plasmodium falciparum)

AQR [nucleoplasm] (Rattus norvegicus)

AQR [nucleoplasm] (Sus scrofa)

salsa [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of AQR [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of AQR [nucleoplasm] (Schizosaccharomyces pombe)

emb-4 [nucleoplasm] (Caenorhabditis elegans)

aqr [nucleoplasm] (Danio rerio)

aqr [nucleoplasm] (Dictyostelium discoideum)

aqr [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_055506.1

OpenTargets

ENSG00000021776

HPA

ENSG00000021776-AQR

GeneCards

O60306

Ensembl

ENSG00000021776, ENST00000156471, ENSP00000156471

PRO

O60306

Pharos - Targets

O60306

PDB

7W5A, 6ICZ, 6ID1, 8CH6, 6ID0, 7W59, 8C6J, 7ABI, 5MQF, 6FF7, 6QDV, 7A5P, 5XJC, 4PJ3, 5Z57, 5Z56, 5YZG, 7W5B

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.731	5
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.648	4
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.648	4
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.648	5
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.648	4
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.648	5
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.648	4
UniProt:Q9CSN1 Snw1	1	Snw1 [nucleoplasm] (R-MMU-2065315)	0.564	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.528	2
UniProt:P62308 SNRPG	2	SNRPG [nucleoplasm] (R-HSA-71909) SNRPG [cytosol] (R-HSA-191827)	0.528	3
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.528	2
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.528	2
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.527	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2

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