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SF3B4 [nucleoplasm]
Stable Identifier
R-HSA-71975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SAP49, Splicing factor 3B subunit 4 (Spliceosome associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA splicing factor SF3b 49 kDa subunit), Splicing factor 3B subunit 4, Spliceosome associated protein 49, SAP 49, SF3b50, Pre-mRNA splicing factor SF3b 49 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C complex (Homo sapiens)
Spliceosomal Active C Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C Complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
U2 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
mRNA Splicing - Minor Pathway (Homo sapiens)
ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of AT-AC A complex (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of AT-AC B Complex (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
Formation of AT-AC C complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U12 snRNP [nucleoplasm] (Homo sapiens)
SF3B [nucleoplasm] (Homo sapiens)
SF3B4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15427 SF3B4
Gene Names
SF3B4, SAP49
Chain
initiator methionine:1, chain:2-424
Reference Genes
BioGPS Gene:10262 SF3B4
COSMIC (genes):SF3B4 SF3B4
CTD Gene:10262 SF3B4
dbSNP Gene:10262 SF3B4
ENSEMBL:ENSG00000143368 SF3B4
HGNC:10771 SF3B4
KEGG Gene (Homo sapiens):10262 SF3B4
Monarch:10262 SF3B4
NCBI Gene:10262 SF3B4
OMIM:605593 SF3B4
UCSC:Q15427 SF3B4
Reference Transcript
RefSeq:NM_005850.4 SF3B4
Other Identifiers
0003520397
10262
11724493_s_at
11724494_x_at
11744950_s_at
16692656
209044_PM_x_at
209044_x_at
2434160
2434161
2434162
2434163
2434164
2434165
2434166
2434167
2434170
2434171
33909_at
3541040
3541043
3541048
7919659
A_23_P35131
GE61193
GO:0000375
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005681
GO:0005684
GO:0005689
GO:0006397
GO:0008150
GO:0008380
GO:0032991
GO:0034641
GO:0043226
GO:0048026
GO:0071005
GO:1990935
HMNXSV003044244
ILMN_1722648
PH_hs_0030054
TC01003196.hg
g13279088_3p_at
g13279088_3p_x_at
Participates
as a component of
SF3B [nucleoplasm] (Homo sapiens)
Inferred To
sap-49 [nucleoplasm]
(Caenorhabditis elegans)
Sf3b4 [nucleoplasm]
(Mus musculus)
Sf3b4 [nucleoplasm]
(Rattus norvegicus)
sf3b4 [nucleoplasm]
(Danio rerio)
sf3b4 [nucleoplasm]
(Xenopus tropicalis)
Spx [nucleoplasm]
(Drosophila melanogaster)
SF3B4 [nucleoplasm]
(Bos taurus)
SF3B4 [nucleoplasm]
(Canis familiaris)
SF3B4 [nucleoplasm]
(Gallus gallus)
SF3B4 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005841.1
OpenTargets
ENSG00000143368
GeneCards
Q15427
HPA
ENSG00000143368-SF3B4
Ensembl
ENST00000271628
,
ENSG00000143368
,
ENSP00000271628
PRO
Q15427
Pharos - Targets
Q15427
Orphanet
21159
PDB
5Z57
,
6QX9
,
6AH0
,
7DVQ
,
7ONB
,
5GVQ
,
5Z56
,
6AHD
,
7ABH
,
6Y5Q
,
7ABI
,
6Y53
,
7ABG
,
1X5T
,
5Z58
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.781
7
UniProt:Q9BUJ2 HNRNPUL1
1
HNRNPUL1 [nucleoplasm]
(R-HSA-72106)
0.666
4
UniProt:P42685 FRK
4
FRK [specific granule lumen]
(R-HSA-6801037)
p-Y387-FRK [cytosol]
(R-HSA-8847965)
FRK [azurophil granule lumen]
(R-HSA-6799142)
FRK [extracellular region]
(R-HSA-6806235)
0.666
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.573
2
UniProt:P20081
1
FPR1 [cytosol]
(R-SCE-2026007)
0.556
3
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
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