Reactome | MAGOH [nucleoplasm]

MAGOH [nucleoplasm]

Stable Identifier

R-HSA-156658

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

magoh

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Axon guidance (Homo sapiens)
  - Signaling by ROBO receptors (Homo sapiens)
    - Regulation of expression of SLITs and ROBOs (Homo sapiens)
      - Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
    - mRNA polyadenylation (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
        
        Spliced mRNP [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
        
        pre-EJC complex [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
      - Formation of Exon Junction Complex (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)
        
        pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
        
        pre-EJC complex [nucleoplasm] (Homo sapiens)
        
        Magoh-Y14 complex [nucleoplasm] (Homo sapiens)
        
        MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)
        
        MAGOH [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61326 MAGOH

Gene Names

MAGOH, MAGOHA

Chain

chain:1-146

Reference Genes

BioGPS Gene:4116 MAGOH

COSMIC (genes):MAGOH MAGOH

CTD Gene:4116 MAGOH

dbSNP Gene:4116 MAGOH

ENSEMBL:ENSG00000162385 MAGOH

HGNC:6815 MAGOH

KEGG Gene (Homo sapiens):4116 MAGOH

Monarch:4116 MAGOH

NCBI Gene:4116 MAGOH

OMIM:602603 MAGOH

UCSC:P61326 MAGOH

Reference Transcript

RefSeq:NM_002370.3 MAGOH

Other Identifiers

0005690020

11724797_a_at

11724798_x_at

11747761_a_at

11747762_x_at

15425

16687342

1P27

210092_at

210093_s_at

2413181

2413182

2413183

2413186

2413192

2413195

2413197

2413198

2HYI

2J0Q

2J0S

2XB2

3EX7

40036_at

4116

43036

47754

7916274

A_23_P200216

AAC39606

AAD32457

AAH18211

AF035940

AF067173

AK297895

AK312113

AL606760

BAG35049

BAG60216

BC018211

CAB015425

CCDS577

CH471059

EAX06747

EAX06748

ENSG00000162385

ENSP00000360521

ENSP00000360525

ENST00000371466

ENST00000371466.4

ENST00000371470

ENST00000371470.7

EntrezGene:4116

EntrezGene:MAGOH

g4894379_3p_a_at

GE58285

GO:0000184

GO:0000381

GO:0000398

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0006397

GO:0006405

GO:0006406

GO:0006412

GO:0006417

GO:0006810

GO:0006913

GO:0008150

GO:0008380

GO:0009056

GO:0009058

GO:0015031

GO:0016607

GO:0031124

GO:0032991

GO:0034641

GO:0034655

GO:0035145

GO:0043226

GO:0051028

GO:0071013

HGNC:6815

HPA043036

HPA047754

ILMN_1814396

ILMN_2215656

IPR004023

IPR036605

MAGOH

MAGOH-201

MAGOH-202

MIM:602603

NM_002370

NP_002361

PF02792

PH_hs_0025145

TC01002668.hg

UPI0000022F39

UPI0000204396

Participant Of

hasMember

MAGOH,MAGOHB [nucleoplasm]

Inferred To

MAGOH [nucleoplasm] (Bos taurus)

MAGOH [nucleoplasm] (Caenorhabditis elegans)

MAGOH [nucleoplasm] (Canis familiaris)

MAGOH [nucleoplasm] (Danio rerio)

MAGOH [nucleoplasm] (Dictyostelium discoideum)

MAGOH [nucleoplasm] (Drosophila melanogaster)

MAGOH [nucleoplasm] (Mus musculus)

MAGOH [nucleoplasm] (Plasmodium falciparum)

MAGOH [nucleoplasm] (Rattus norvegicus)

MAGOH [nucleoplasm] (Schizosaccharomyces pombe)

MAGOH [nucleoplasm] (Sus scrofa)

MAGOH [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002361.1

OpenTargets

ENSG00000162385

GeneCards

P61326

PRO

P61326

PDB

2J0Q, 3EX7, 1P27, 2J0S, 2XB2, 2HYI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.955	23
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.938	30
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.773	7
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.696	5
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.564	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.488	2
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.488	2
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.462	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.462	2