Reactome | p-Y297,304,307-PRMT5 [nucleoplasm]

p-Y297,304,307-PRMT5 [nucleoplasm]

Stable Identifier

R-HSA-5211300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JBP1

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External Reference Information

External Reference

UniProt:O14744 PRMT5

Gene Names

PRMT5, HRMT1L5, IBP72, JBP1, SKB1

Chain

chain:1-637, initiator methionine:, chain:2-637

Reference Genes

BioGPS Gene:10419 PRMT5

COSMIC (genes):PRMT5 PRMT5

CTD Gene:10419 PRMT5

dbSNP Gene:10419 PRMT5

ENSEMBL:ENSG00000100462 PRMT5

HGNC:10894 PRMT5

KEGG:hsa:10419 PRMT5

Monarch:10419 PRMT5

NCBI Gene:10419 PRMT5

OMIM:604045 PRMT5

UCSC:O14744 PRMT5

Reference Transcript

Other Identifiers

10419

11755951_s_at

1564520_PM_s_at

1564520_s_at

1564521_PM_x_at

1564521_x_at

16790556

217786_PM_at

217786_at

3556925

3556926

3556927

3556928

3556929

3556930

3556931

3556932

3556933

3556934

3556935

3556936

3556937

3556938

3556939

3556940

3556941

3556942

3556943

3556944

3556945

3556946

3556947

3556948

3556949

3556950

3556951

3556952

3556953

3556954

3556955

3556956

3556957

3556958

3556959

3556960

56550_at

57340_s_at

7977820

AF015913_at

A_23_P76851

A_24_P298420

GE61958

GO:0000387

GO:0000785

GO:0002039

GO:0003677

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0006325

GO:0006338

GO:0006353

GO:0006355

GO:0006479

GO:0007088

GO:0008168

GO:0008276

GO:0008327

GO:0008469

GO:0010468

GO:0016274

GO:0016740

GO:0018216

GO:0032259

GO:0032922

GO:0032991

GO:0034709

GO:0035097

GO:0035243

GO:0035246

GO:0042054

GO:0042118

GO:0042802

GO:0043021

GO:0043226

GO:0044020

GO:0044027

GO:0044877

GO:0045596

GO:0045892

GO:0046982

GO:0048026

GO:0048511

GO:0048714

GO:0048856

GO:0060090

GO:0065003

GO:0070372

GO:0070888

GO:0090161

GO:0097421

GO:0140096

GO:0140110

GO:0140938

GO:1901796

GO:1904992

HMNXSV003013590

ILMN_1811955

ILMN_2403889

PH_hs_0017523

TC14000940.hg

g5174682_3p_at

g5174682_3p_s_at

Participates

as an output of

PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)

This entity regulates

Negatively

PRMT5 binds WDR77 (Homo sapiens)

Other forms of this molecule

PRMT5 [cytosol]

PRMT5 [nucleoplasm]

Inferred To

phospho-Prmt5 [nucleoplasm] (Rattus norvegicus)

phospho-PRMT5 [nucleoplasm] (Canis familiaris)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Bos taurus)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Drosophila melanogaster)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Mus musculus)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Sus scrofa)

phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 297

Coordinate

297

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 304

Coordinate

304

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 307

Coordinate

307

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001269885.1, NP_001269884.1, NP_006100.2, NP_001034708.1, NP_001269882.1

Guide to Pharmacology - Targets

1256

OpenTargets

ENSG00000100462

ENSEMBL

ENST00000553897, ENSP00000452555, ENSP00000216350, ENST00000397440, ENST00000397441, ENSP00000380583, ENSP00000319169, ENSP00000380582, ENST00000216350, ENST00000324366

ZINC - Substances

ANM5_HUMAN

ZINC target

O14744

PRO

O14744

GlyGen

O14744

PDB

7SER, 6K1S, 7ZV2, 4X61, 7MXA, 8VEU, 7S0U, 7ZUP, 5EMK, 8VEX, 7U30, 8VEO, 6V0O, 5EMM, 7ZVL, 7BO7, 6UXX, 7MXG, 7MXN, 7L1G, 6CKC, 7MXC, 7KID, 4X63, 7UYF, 7S1Q, 6V0P, 7ZVU, 8CTB, 7SES, 4X60, 7ZUQ, 7UOH, 7MX7, 8VET, 5EML, 8CYI, 6RLL, 6UXY, 5EMJ, 8VEY, 8VEW, 6V0N, 7BOC, 7UY1, 7M05, 5C9Z, 7ZUY, 8CSG, 4GQB, 7ZUU, 8G1U, 6RLQ, 7KIB, 7KIC, 7S1R, 5FA5, 6UGH, 7S1S, 7S1P

IntEnz

2.1.1.320

HPA

ENSG00000100462-PRMT5

Pharos - Targets

O14744

ZINC - Predictions - Purchasable

ANM5_HUMAN

HMDB Protein

HMDBP01721

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.96	17
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.826	9
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.756	6
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.708	6
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.706	7
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.693	3
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.669	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.666	4
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.646	8
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.646	3
UniProt:Q86U06 RBM23			0.635	3
UniProt:Q91XC0 Ajuba	3	Ajuba [nucleoplasm] (R-MMU-5687969) phospho-Ajuba [cytosol] (R-MMU-2574841) Ajuba [cytosol] (R-MMU-2564698)	0.623	4
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.611	4
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.602	4
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.597	3
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.591	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	2
UniProt:P24928 POLR2A	7	POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543)	0.558	6
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.556	3
UniProt:O15197-2 EPHB6			0.556	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.556	3
UniProt:P03952 KLKB1	5	KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-390) [extracellular region] (R-HSA-158239) KLKB1(20-638) [plasma membrane] (R-HSA-158385) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(391-638) [plasma membrane] (R-HSA-158277)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.556	3
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P21964-2 COMT			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q08289 CACNB2	2	CACNB2 [cytosol] (R-HSA-210496) CACNB2 [plasma membrane] (R-HSA-532200)	0.556	3
UniProt:Q96E35 ZMY19			0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	2
UniProt:P98179 RBM3			0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.527	3
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	3
UniProt:Q14011 CIRBP			0.527	3
UniProt:P62312 LSM6	2	LSM6 [nucleoplasm] (R-HSA-6806794) LSM6 [cytosol] (R-HSA-429936)	0.527	3
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	3
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q86UQ8-1 NFE4			0.525	2
UniProt:P31269 HXA9			0.524	4
UniProt:Q8WVJ2 NUDC2			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:Q8TE85 GRHL3			0.508	2
UniProt:Q8N8U2 CDYL2			0.508	2
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.508	2
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.499	3
UniProt:P03418 N	4	p-N [viral capsid] (R-RSY-9835206) Nascent N [cytosol] (R-RSY-9831167) p-N [cytosol] (R-RSY-9823348) N [viral capsid] (R-RSY-9823364)	0.499	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	3

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