Reactome | 2xMe-SNRPD3 [cytosol]

2xMe-SNRPD3 [cytosol]

Stable Identifier

R-HSA-191781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

dimethylated Sm protein D3, SMD3_HUMAN, snRNP core protein D3, Small nuclear ribonucleoprotein Sm D3, Sm-D3

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 modulates host translation machinery (Homo sapiens)
        
        snRNP complex assembly (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        snRNP Sm core complex [cytosol] (Homo sapiens)
        
        2xMe-SNRPD3 [cytosol] (Homo sapiens)
        
        Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        snRNP Sm core complex [cytosol] (Homo sapiens)
        
        2xMe-SNRPD3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62318 SNRPD3

Gene Names

SNRPD3

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:6634 SNRPD3

COSMIC (genes):SNRPD3 SNRPD3

CTD Gene:6634 SNRPD3

dbSNP Gene:6634 SNRPD3

ENSEMBL:ENSG00000100028.12 SNRPD3

HGNC:11160 SNRPD3

KEGG Gene (Homo sapiens):6634 SNRPD3

Monarch:6634 SNRPD3

NCBI Gene:6634 SNRPD3

OMIM:601062 SNRPD3

UCSC:P62318 SNRPD3

Reference Transcript

Other Identifiers

11717431_a_at

16928282

202567_PM_at

202567_at

3940192

3940193

3940194

3940196

3940198

3940199

3940200

3940201

3940202

3940203

3940204

3940205

3940206

3940207

3940208

3940212

40150_at

44100_at

63879_at

6634

77648_at

8071920

A_14_P114019

A_23_P132216

A_33_P3314511

A_33_P3396239

GE61234

GE87971

GO:0000243

GO:0000387

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005682

GO:0005683

GO:0005685

GO:0005686

GO:0005687

GO:0005689

GO:0005697

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006479

GO:0008380

GO:0016071

GO:0016604

GO:0019899

GO:0030532

GO:0034709

GO:0034715

GO:0034719

GO:0036211

GO:0036261

GO:0043226

GO:0046540

GO:0065003

GO:0070034

GO:0071005

GO:0071007

GO:0071011

GO:0071013

GO:0071208

GO:0071209

GO:0097526

GO:1903241

GO:1990904

HMNXSV003039054

HMNXSV003044545

ILMN_1794599

PH_hs_0024004

TC22001459.hg

U15009_at

g4759159_3p_at

Participates

as an input of

Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)

as a component of

snRNP Sm core complex [cytosol] (Homo sapiens)

Other forms of this molecule

2xMe-SNRPD3 [nucleoplasm]

SNRPD3 [nucleoplasm]

Inferred To

snrpD3 [cytosol] (Dictyostelium discoideum)

2xMe-SNRPD3 [cytosol] (Canis familiaris)

2xMe-SNRPD3 [cytosol] (Plasmodium falciparum)

snr-1 [cytosol] (Caenorhabditis elegans)

Snrpd3 [cytosol] (Mus musculus)

Snrpd3 [cytosol] (Rattus norvegicus)

smd3 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of 2xMe-SNRPD3 [cytosol] (Xenopus tropicalis)

SNRPD3 [cytosol] (Bos taurus)

SNRPD3 [cytosol] (Danio rerio)

SNRPD3 [cytosol] (Gallus gallus)

SNRPD3 [cytosol] (Sus scrofa)

SMD3 [cytosol] (Saccharomyces cerevisiae)

SmD3 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

monomethylated residue at unknown position

PsiMod Name

monomethylated residue [MOD:00599]

PsiMod Definition

A protein modification that effectively replaces one hydrogen atom with one methyl group.

Name

monomethylated residue at unknown position

PsiMod Name

monomethylated residue [MOD:00599]

PsiMod Definition

A protein modification that effectively replaces one hydrogen atom with one methyl group.

Cross References

RefSeq

NP_001265585.1, NP_004166.1

OpenTargets

ENSG00000100028

HPA

ENSG00000100028-SNRPD3

GeneCards

P62318

Ensembl

ENSP00000215829, ENST00000402849, ENSP00000385266, ENSG00000100028, ENST00000215829

PRO

P62318

Pharos - Targets

P62318

PDB

6QX9, 7ABI, 6AHD, 3JCR, 7DVQ, 4PJO, 7W59, 7ABG, 7EVO, 6ID1, 7W5B, 6Y53, 6V4X, 3CW1, 6ICZ, 3PGW, 7W5A, 7A5P, 5MQF, 6QDV, 4WZJ, 6ID0, 6FF7, 1D3B, 5YZG, 6QW6, 5O9Z, 6AH0, 6Y5Q, 5XJC, 7B0Y, 5Z57, 5Z56, 3VRI, 5Z58

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.835	9
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.742	5
UniProt:P14678 SNRPB	4	Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.736	4
UniProt:Q9UK45 LSM7	2	LSM7 [nucleoplasm] (R-HSA-6806802) LSM7 [cytosol] (R-HSA-2028610)	0.668	3
UniProt:P84090 ERH			0.576	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.527	3
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [nucleoplasm] (R-HSA-191765) GEMIN5 [cytosol] (R-HSA-191833)	0.527	2
UniProt:Q9Y6A4 CFA20			0.508	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.508	2
UniProt:P14678-2 SNRPB			0.499	2