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K48polyUb-DDX41 [cytosol]
Stable Identifier
R-HSA-3134942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DEAD box protein 41, Probable ATP-dependent RNA helicase DDX41
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DDX41 ubiquitination by TRIM21 (Homo sapiens)
K48polyUb-DDX41:TRIM21 [cytosol] (Homo sapiens)
K48polyUb-DDX41 [cytosol] (Homo sapiens)
K48polyUb-DDX41 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJV9 DDX41
Gene Names
DDX41, ABS
Chain
chain:1-622
Reference Genes
BioGPS Gene:51428 DDX41
COSMIC (genes):DDX41 DDX41
CTD Gene:51428 DDX41
dbSNP Gene:51428 DDX41
ENSEMBL:ENSG00000183258 DDX41
ENSEMBL_homo_sapiens_GENE:ENSG00000183258.12 DDX41
HGNC:18674 DDX41
KEGG Gene (Homo sapiens):51428 DDX41
Monarch:51428 DDX41
NCBI Gene:51428 DDX41
OMIM:608170 DDX41
UCSC:Q9UJV9 DDX41
Reference Transcript
RefSeq:NM_001321830.1 DDX41
RefSeq:NM_016222.3 DDX41
RefSeq:NM_001321732.1 DDX41
Other Identifiers
11735689_a_at
17003336
217840_3p_at
217840_PM_at
217840_at
2888905
2888906
2888907
2888909
2888910
2888912
2888914
2888915
2888916
2888917
2888920
2888922
2888923
2888924
2888926
2888928
2888930
2888931
2888934
2889145
2889146
2889147
2889148
2889150
2889151
2889152
2889154
2889156
2889157
2889158
2889160
2889163
2889165
2889166
2889167
2889168
2889171
2889173
2889175
2889176
2889179
51428
65559_s_at
65567_i_at
65568_r_at
8116096
GE61815
GO:0000166
GO:0000398
GO:0003676
GO:0003723
GO:0003724
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005829
GO:0006397
GO:0006915
GO:0008283
GO:0008380
GO:0012501
GO:0016020
GO:0016071
GO:0016787
GO:0016887
GO:0030154
GO:0043226
GO:0046872
GO:0071013
GO:0140098
GO:0140657
HMNXSV003037435
ILMN_1737344
PH_hs_0039850
TC05002112.hg
g7705259_3p_at
g7705259_3p_s_at
Participates
as a member of
K48polyUb-DDX41 [cytosol] (Homo sapiens)
Other forms of this molecule
DDX41 [nucleoplasm]
DDX41 [cytosol]
K48polyUb-DDX41 [cytosol]
Inferred To
ddx41 [cytosol]
(Xenopus tropicalis)
sacy-1 [cytosol]
(Caenorhabditis elegans)
DDX41 [cytosol]
(Bos taurus)
DDX41 [cytosol]
(Canis familiaris)
DDX41 [cytosol]
(Sus scrofa)
K48polyUb-DDX41 [cytosol]
(Gallus gallus)
K48polyUb-DDX41 [cytosol]
(Mus musculus)
K48polyUb-DDX41 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 115
Coordinate
115
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_057306.2
,
NP_001308661.1
,
NP_001308759.1
OpenTargets
ENSG00000183258
HPA
ENSG00000183258-DDX41
GeneCards
Q9UJV9
Ensembl
ENSP00000330349
,
ENST00000330503
,
ENSG00000183258
PRO
Q9UJV9
Pharos - Targets
Q9UJV9
Orphanet
24461
PDB
8C6J
,
5GVR
,
5H1Y
,
5GVS
,
2P6N
HMDB Protein
HMDBP11674
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N5F7 NKAP
1
NKAP [nucleoplasm]
(R-HSA-9769602)
0.716
5
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.643
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.643
4
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.643
3
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.564
2
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q5M9Q1 NKAPL
0.556
5
UniProt:Q96BJ3 AIDA
0.556
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.527
2
UniProt:O75052 CAPON
0.527
3
UniProt:Q9ULJ7 ANR50
0.527
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.527
2
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.527
2
UniProt:P14678 SNRPB
4
SNRPB [nucleoplasm]
(R-HSA-71896)
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [cytosol]
(R-HSA-191798)
2xMe-SNRPB [cytosol]
(R-HSA-192218)
0.527
2
UniProt:Q9Y3M2 CBY1
3
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.508
2
UniProt:Q13595 TRA2A
0.483
2
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.462
3
UniProt:Q6P2Q9 PRPF8
1
PRPF8 [nucleoplasm]
(R-HSA-83810)
0.462
3
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