Reactome | GEMIN8 [cytosol]

GEMIN8 [cytosol]

Stable Identifier

R-HSA-8932878

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gem-associated protein 8, GEMI8_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 modulates host translation machinery (Homo sapiens)
        
        snRNP complex assembly (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN8 [cytosol] (Homo sapiens)
        
        Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol] (Homo sapiens)
        
        SMN:SM protein complex [cytosol] (Homo sapiens)
        
        SMN complex [cytosol] (Homo sapiens)
        
        GEMIN8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NWZ8 GEMIN8

Gene Names

GEMIN8, FAM51A1

Chain

chain:1-242

Reference Genes

BioGPS Gene:54960 GEMIN8

COSMIC (genes):GEMIN8 GEMIN8

CTD Gene:54960 GEMIN8

dbSNP Gene:54960 GEMIN8

ENSEMBL:ENSG00000046647 GEMIN8

HGNC:26044 GEMIN8

KEGG:hsa:54960 GEMIN8

Monarch:54960 GEMIN8

NCBI Gene:54960 GEMIN8

OMIM:300962 GEMIN8

UCSC:Q9NWZ8 GEMIN8

Reference Transcript

Other Identifiers

11729253_a_at

11735749_a_at

11735750_x_at

219252_PM_s_at

219252_s_at

222854_PM_s_at

222854_s_at

230758_PM_at

230758_at

2422230

2422235

3631161

4000268

4000270

4000271

4000272

4000274

4000278

4000279

4000280

4000281

4000282

4000283

4000285

4000286

4000289

4000290

52122_at

54960

56273_at

73757_at

8171373

A_24_P156576

GE55533

GE84987

GO:0000387

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0032797

GO:0034719

GO:0043226

GO:0065003

GO:0097504

HMNXSV003003247

HMNXSV003026585

HMNXSV003049523

Hs.123425.0.A1_3p_at

Hs.44423.0.S1_3p_a_at

ILMN_1748116

ILMN_2364088

PH_hs_0034660

TC0X000870.hg

g8923480_3p_a_at

Participates

as a component of

SMN complex [cytosol] (Homo sapiens)

Other forms of this molecule

GEMIN8 [nucleoplasm]

Inferred To

Ghost homologue of GEMIN8 [cytosol] (Canis familiaris)

Ghost homologue of GEMIN8 [cytosol] (Dictyostelium discoideum)

GEMIN8 [cytosol] (Bos taurus)

GEMIN8 [cytosol] (Caenorhabditis elegans)

GEMIN8 [cytosol] (Gallus gallus)

GEMIN8 [cytosol] (Sus scrofa)

Gemin8 [cytosol] (Mus musculus)

Gemin8 [cytosol] (Rattus norvegicus)

gemin8 [cytosol] (Danio rerio)

gemin8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016885106.1, NP_001035945.1, XP_016885107.1, NP_001035944.1, NP_060326.1

ENSEMBL

ENST00000380523, ENSP00000505279, ENST00000398355, ENSP00000505429, ENSG00000046647, ENST00000680255, ENSP00000369895, ENST00000477386, ENSP00000381398

OpenTargets

ENSG00000046647

GeneCards

GEMIN8

HPA

ENSG00000046647-GEMIN8

PRO

Q9NWZ8

Pharos - Targets

Q9NWZ8

PDB

7BBL

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	4
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	3
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	4
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.527	3