Reactome | TGS1 [nucleoplasm]

TGS1 [nucleoplasm]

Stable Identifier

R-HSA-400176

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PIMT

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
        
        TGS1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96RS0 TGS1

Gene Names

TGS1, HCA137, NCOA6IP, PIMT

Chain

chain:1-853

Reference Genes

BioGPS Gene:96764 TGS1

COSMIC (genes):TGS1 TGS1

CTD Gene:96764 TGS1

dbSNP Gene:96764 TGS1

ENSEMBL:ENSG00000137574 TGS1

HGNC:17843 TGS1

KEGG:hsa:96764 TGS1

Monarch:96764 TGS1

NCBI Gene:96764 TGS1

OMIM:606461 TGS1

UCSC:Q96RS0 TGS1

Reference Transcript

Other Identifiers

11725142_a_at

11755519_x_at

17069045

219231_PM_at

219231_at

222335_PM_at

222335_at

238346_PM_s_at

238346_s_at

3098936

3098937

3098938

3098939

3098940

3098942

3098943

3098944

3098945

3098946

3098947

3098948

3098949

3098950

3098952

3098953

3098954

3098955

3098956

3098957

3098959

3098962

3098963

3098964

3098965

3098966

3098967

3098968

3098969

46444_at

62765_r_at

8146482

96764

A_14_P108934

A_14_P119458

A_33_P3337771

GE87882

GO:0000387

GO:0001510

GO:0003824

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0008168

GO:0008173

GO:0015030

GO:0016740

GO:0022613

GO:0030532

GO:0032259

GO:0036261

GO:0043226

GO:0065003

GO:0071164

GO:0140098

HMNXSV003040426

Hs.29075.1.S1_3p_at

Hs.44888.0.A1_3p_at

ILMN_1651506

PH_hs_0010653

TC08000382.hg

g13376235_3p_at

Participates

as a member of

Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TGS1 [cytosol]

Inferred To

Tgs1 [nucleoplasm] (Drosophila melanogaster)

tgs1 [nucleoplasm] (Xenopus tropicalis)

TGS1 [nucleoplasm] (Bos taurus)

TGS1 [nucleoplasm] (Canis familiaris)

TGS1 [nucleoplasm] (Gallus gallus)

TGS1 [nucleoplasm] (Mus musculus)

TGS1 [nucleoplasm] (Rattus norvegicus)

TGS1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_079107.6, NP_001304831.1

ENSEMBL

ENSP00000260129, ENST00000260129

OpenTargets

ENSG00000137574

HPA

ENSG00000137574-TGS1

PRO

Q96RS0

Pharos - Targets

Q96RS0

HMDB Protein

HMDBP11975

PDB

3GDH, 3EGI

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.744	5
UniProt:Q9Y2X3 NOP58	3	polySUMO2-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570460) monoSUMO1-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570470) NOP58 [nucleoplasm] (R-HSA-4570488)	0.656	3
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	3
UniProt:Q86UR1-2 NOXA1			0.556	3
UniProt:P36508 ZNF76			0.556	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	4
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	2
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.527	3
UniProt:Q8N128 F177A			0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	3

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