Reactome | RIOK1 [cytosol]

RIOK1 [cytosol]

Stable Identifier

R-HSA-6791525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase RIO1 ecNumber2.7.11.1/ecNumber, RIOK1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BRS2 RIOK1

Gene Names

RIOK1, RIO1

Chain

chain:1-568

Reference Genes

BioGPS Gene:83732 RIOK1

COSMIC (genes):RIOK1 RIOK1

CTD Gene:83732 RIOK1

dbSNP Gene:83732 RIOK1

ENSEMBL:ENSG00000124784 RIOK1

ENSEMBL_homo_sapiens_GENE:ENSG00000124784.9 RIOK1

HGNC:18656 RIOK1

Monarch:83732 RIOK1

NCBI Gene:83732 RIOK1

OMIM:617753 RIOK1

UCSC:Q9BRS2 RIOK1

Reference Transcript

RefSeq:NM_031480.2 RIOK1

Other Identifiers

11730139_a_at

11733924_a_at

11733925_a_at

17004582

224450_PM_s_at

224450_s_at

2893722

2893723

2893726

2893727

2893729

2893730

2893731

2893732

2893735

2893736

2893738

2893739

2893740

2893741

2893742

2893744

2893745

2893747

2893749

2893752

2893753

2893756

2893757

2893758

51703_at

73522_at

81163_at

8116760

83732

A_14_P120232

A_24_P8088

A_24_P93798

GE83260

GO:0000166

GO:0003824

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0016301

GO:0016310

GO:0016740

GO:0016787

GO:0030490

GO:0030688

GO:0034708

GO:0042254

GO:0042274

GO:0043226

GO:0046872

GO:0106310

GO:0140096

GO:2000234

HMNXSV003055170

ILMN_1652487

ILMN_1797534

PH_hs_0025610

TC06000058.hg

g13543921_3p_s_at

Participates

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Other forms of this molecule

RIOK1 [nucleoplasm]

Inferred To

RIOK1 [cytosol] (Bos taurus)

RIOK1 [cytosol] (Caenorhabditis elegans)

RIOK1 [cytosol] (Canis familiaris)

RIOK1 [cytosol] (Drosophila melanogaster)

RIOK1 [cytosol] (Mus musculus)

RIOK1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_113668.2

ZINC - World Drugs

RIOK1_HUMAN

Guide to Pharmacology - Targets

2186

OpenTargets

ENSG00000124784

ZINC - FDA approved

RIOK1_HUMAN

ZINC - Substances

RIOK1_HUMAN

ZINC target

Q9BRS2

ZINC - Biogenic

RIOK1_HUMAN

PRO

Q9BRS2

PDB

6ZXF, 6ZV6, 6ZXH, 7BOC, 6V0N, 6ZXE, 6ZXG, 6G5I, 6ZXD, 4OTP

ZINC - Investigational

RIOK1_HUMAN

HPA

ENSG00000124784-RIOK1

GeneCards

Q9BRS2

Ensembl

ENST00000379834, ENSP00000369162, ENSG00000124784

Pharos - Targets

Q9BRS2

ZINC - Predictions - Purchasable

RIOK1_HUMAN

HMDB Protein

HMDBP01414

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.623	5
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	2
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.508	2