Reactome | PAB1 [cytosol]

PAB1 [cytosol]

Stable Identifier

R-SCE-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PABPC1, P04147

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Deadenylation-dependent mRNA decay (Saccharomyces cerevisiae)
  - Deadenylation of mRNA (Saccharomyces cerevisiae)
    - PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
      - Partially Deadenylated mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
      - Translatable mRNA Complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)
        
        PAB1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P04147

Gene Names

PAB1

Reference Genes

BioGPS Gene:856912 PAB1

ENSEMBL:YER165W

KEGG:sce:YER165W PAB1

Monarch:856912 PAB1

NCBI Gene:856912 PAB1

SGD:YER165W

UCSC:P04147 PAB1

Reference Transcript

RefSeq:NM_001179055.1 PAB1

Other Identifiers

856912

GO:0003674

GO:0003676

GO:0003682

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006397

GO:0006417

GO:0006446

GO:0008143

GO:0008150

GO:0008266

GO:0008428

GO:0010494

GO:0015931

GO:0019899

GO:0030234

GO:0030674

GO:0031124

GO:0034236

GO:0051028

GO:0060211

GO:0140693

GO:1990841

GO:1990904

Participates

as a member of

Homologues of PABPC1 [cytosol] (Saccharomyces cerevisiae)

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011092.1

ENSEMBL

YER165W_mRNA, YER165W, YER165W

PRO

P04147

PDB

6R5K, 1IFW

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.669	3
UniProt:P47047	1	SKIV2L2 [nucleoplasm] (R-SCE-6791189)	0.564	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P34160	2	STO1 [nucleoplasm] (R-SCE-51469) STO1 [cytosol] (R-SCE-162459)	0.527	2
UniProt:Q07381	2	TSR1 [nucleoplasm] (R-SCE-6791574) TSR1 [cytosol] (R-SCE-6791570)	0.527	2

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