Reactome | RBM8A [cytosol]

RBM8A [cytosol]

Stable Identifier

R-HSA-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RBM8A/Y14

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5S9 RBM8A

Gene Names

RBM8A, RBM8, HSPC114, MDS014

Chain

initiator methionine:, chain:2-174

Reference Genes

BioGPS Gene:9939 RBM8A

COSMIC (genes):RBM8A RBM8A

CTD Gene:9939 RBM8A

dbSNP Gene:9939 RBM8A

ENSEMBL:ENSG00000265241 RBM8A

HGNC:9905 RBM8A

KEGG:hsa:9939 RBM8A

Monarch:9939 RBM8A

NCBI Gene:9939 RBM8A

OMIM:605313 RBM8A

UCSC:Q9Y5S9 RBM8A

Reference Transcript

RefSeq:NM_005105.4 RBM8A

Participates

as a component of

Magoh-Y14 complex [cytosol] (Homo sapiens)

Other forms of this molecule

RBM8A [nucleoplasm]

Inferred To

tsu [cytosol] (Drosophila melanogaster)

Rbm8a [cytosol] (Mus musculus)

Rbm8a [cytosol] (Rattus norvegicus)

RBM8A [cytosol] (Canis familiaris)

RBM8A [cytosol] (Gallus gallus)

RBM8A [cytosol] (Plasmodium falciparum)

RBM8A [cytosol] (Schizosaccharomyces pombe)

RBM8A [cytosol] (Sus scrofa)

rbm8a [cytosol] (Danio rerio)

rbm8a [cytosol] (Xenopus tropicalis)

rnp-4 [cytosol] (Caenorhabditis elegans)

Ghost homologue of RBM8A [cytosol] (Bos taurus)

Ghost homologue of RBM8A [cytosol] (Saccharomyces cerevisiae)

rbm8A [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000265241

ENSEMBL

ENST00000583313, ENSP00000463058, ENST00000369307, ENSP00000488265, ENSP00000358313, ENST00000691760, ENST00000632555, ENSP00000510519, ENSG00000265241

HPA

ENSG00000265241-RBM8A

GeneCards

RBM8A

PRO

Q9Y5S9

Pharos - Targets

Q9Y5S9

Orphanet

RBM8A

GlyGen

Q9Y5S9

PDB

2HYI, 1P27, 5YZG, 7W5A, 6QDV, 7W59, 9FMD, 6ICZ, 3EX7, 7A5P, 5XJC, 8I0W, 2J0S, 2J0Q, 2XB2, 7W5B, 7ZNJ, 8C6J

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.947	22
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.914	10
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.857	6
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.725	5
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.564	2
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.527	2
UniProt:Q13838 DDX39B	2	DDX39B [nucleoplasm] (R-HSA-8849139) DDX39B [cytosol] (R-HSA-9715154)	0.527	3
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.512	3