Reactome | Translatable mRNA Complex [cytosol]

Translatable mRNA Complex [cytosol]

Stable Identifier

R-HSA-429977

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

mRNA's that are ready for translation have a circular structure caused by interaction between PABP bound to the 3' poly(A) tail and the eIF4E-eIF4G-PAIP complex bound to the 7-methylguanosine cap. The interaction between poly(A)-PABP and the eIF4G-eIF4E complex stimulates affinity of eIF4E for the cap and improves translation.

Literature References

PubMed ID	Title	Journal	Year
9714706	A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation Gallie, DR	Gene	1998
12138105	Free poly(A) stimulates capped mRNA translation in vitro through the eIF4G-poly(A)-binding protein interaction Kean, KM, Michel, YM, Borman, AM, Malnou, CE	J Biol Chem	2002
15355595	The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective Gorgoni, B, Gray, NK	Brief Funct Genomic Proteomic	2004

Participants

components

Participates

as an input of

PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)

Inferred To

Translatable mRNA Complex [cytosol] (Bos taurus)

Translatable mRNA Complex [cytosol] (Canis familiaris)

Translatable mRNA Complex [cytosol] (Danio rerio)

Translatable mRNA Complex [cytosol] (Drosophila melanogaster)

Translatable mRNA Complex [cytosol] (Gallus gallus)

Translatable mRNA Complex [cytosol] (Mus musculus)

Translatable mRNA Complex [cytosol] (Rattus norvegicus)

Translatable mRNA Complex [cytosol] (Sus scrofa)

Translatable mRNA Complex [cytosol] (Xenopus tropicalis)

Cite Us!