Reactome | Homologues of PABPC1 [cytosol]

Homologues of PABPC1 [cytosol]

Stable Identifier

R-DDI-156803-5

Type

Set [DefinedSet]

Species

Dictyostelium discoideum

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of RNA (Dictyostelium discoideum)

- Nonsense-Mediated Decay (NMD) (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)
- Regulation of mRNA stability by proteins that bind AU-rich elements (Dictyostelium discoideum)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Dictyostelium discoideum)
    - AUF1 (hnRNP D0) is ubiquitinylated (Dictyostelium discoideum)
      - AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Dictyostelium discoideum)
        
        Homologues of PABPC1 [cytosol] (Dictyostelium discoideum)

Participants

members

Participates

as a component of

Inferred From

PABPC1 [cytosol] (Homo sapiens)