Reactome | rnp24 [cytosol]

rnp24 [cytosol]

Stable Identifier

R-SPO-156803-2

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

PABPC1, Q09100

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Deadenylation-dependent mRNA decay (Schizosaccharomyces pombe)
  - Deadenylation of mRNA (Schizosaccharomyces pombe)
    - PAN2-PAN3 complex partially deadenylates mRNA (Schizosaccharomyces pombe)
      - Partially Deadenylated mRNA Complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
      - Translatable mRNA Complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Schizosaccharomyces pombe)
      - Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
      - mRNA Cleaved by SMG6 [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
      - mRNA Cleaved by SMG6 [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)
        
        rnp24 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q09100

Gene Names

rnp24

Reference Genes

BioGPS Gene:2542965 rnp24

ENSEMBL:SPAC3G6.04

KEGG:spo:2542965 rnp24

Monarch:2542965 rnp24

NCBI Gene:2542965 rnp24

PomBase:SPAC3G6.04

UCSC:Q09100 rnp24

Reference Transcript

RefSeq:NM_001020401.2 rnp24

Participates

as a member of

Homologues of PABPC1 [cytosol] (Schizosaccharomyces pombe)

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_594970.1

PRO

Q09100

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